Aspirin Desensitization: What It Is and Who Needs It

When someone has aspirin desensitization, a medical procedure that safely reintroduces aspirin to people with severe reactions. Also known as aspirin tolerance induction, it’s not a cure—but for many, it’s the only way to manage chronic sinus issues, asthma, and nasal polyps without avoiding all NSAIDs. This isn’t for everyone. It’s meant for those with aspirin-exacerbated respiratory disease, a condition where aspirin and other NSAIDs trigger severe breathing problems, often called AERD. People with AERD don’t just get a stomach ache or rash—they can have full asthma attacks, swelling in the sinuses, and trouble breathing within hours of taking even a small dose of aspirin or ibuprofen.

Most people who think they’re allergic to aspirin aren’t. True allergies involve the immune system making IgE antibodies. AERD is different. It’s an intolerance tied to how the body handles inflammation chemicals called leukotrienes. When aspirin blocks one pathway, the body overproduces others, causing inflammation in the airways. That’s why avoiding all NSAIDs doesn’t fix the root problem—it just hides it. Aspirin desensitization works by slowly giving increasing doses under medical supervision, teaching the body to tolerate it without triggering a reaction. Once done, patients can often stop using expensive biologics, reduce nasal polyp growth, and even cut down on sinus surgeries.

It’s not a quick fix. The process takes one to three days in a hospital or clinic, with constant monitoring. But for those who complete it, the benefits last. Studies show over 70% of patients with AERD see long-term improvement in breathing, sense of smell, and quality of life. This isn’t just about aspirin. Once desensitized, many can also take other NSAIDs like ibuprofen or naproxen safely. That matters because pain and inflammation don’t stop just because you have AERD. And if you’ve been told to avoid all pain relievers for years, this changes everything.

Aspirin desensitization doesn’t replace other treatments—it complements them. It works alongside nasal sprays, inhalers, and even biologics. But for many, it’s the missing piece. If you’ve struggled with chronic sinus infections, constant nasal congestion, or asthma flare-ups after taking Advil or Aleve, this might be the answer you’ve been told doesn’t exist. The science is solid. The risks are managed. And the results? Life-changing for those who qualify.

Aspirin-Exacerbated Respiratory Disease: Understanding Asthma and NSAID Sensitivity

Aspirin-Exacerbated Respiratory Disease (AERD) is a severe condition linking asthma, nasal polyps, and NSAID sensitivity. Learn how it develops, why it's often missed, and how aspirin desensitization can change your prognosis.