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Visken Price Comparison

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Visken Prices from Pharma Passport

Visken 5mg

90
Brand

$66.00

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$ 0.73

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5.71%
When you buy 1 container of Visken 5mg for $66.00 at Pharma Passport compared to the max price for 90 of $70.00.
1 container (90): Visken 5mg
$66.00
Regular Shipping:
$9.95
Total:
$75.95
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Visken Prices from Online Pharmacies Canada

Visken 5mg

90
Brand

$66.00

viewdetail

$ 0.73

Go To STORE
5.71%
When you buy 1 container of Visken 5mg for $66.00 at Online Pharmacies Canada compared to the max price for 90 of $70.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (90): Visken 5mg
$66.00
Regular Shipping:
$9.95
Total:
$75.95
Go To Store

Visken Prices from Quality Prescription Drugs

Visken 5mg

90
Brand

$66.16

viewdetail

$ 0.74

Go To STORE
5.49%
When you buy 1 container of Visken 5mg for $66.16 at Quality Prescription Drugs compared to the max price for 90 of $70.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (90): Visken 5mg
$66.16
Regular Shipping:
$9.00
Total:
$75.16
Go To Store

Visken Prices from Online Canadian Pharmacy

Visken 5mg

90
Brand

$69.31

viewdetail

$ 0.77

Go To STORE
0.99%
When you buy 1 container of Visken 5mg for $69.31 at Online Canadian Pharmacy compared to the max price for 90 of $70.00.
1 container (90): Visken 5mg
$69.31
Regular Shipping:
$0.00
Total:
$69.31
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Visken Prices from PrescriptionPoint

Visken 5mg

90
Brand

$70.00

viewdetail

$ 0.78

Go To STORE
0.00%
When you buy 1 container of Visken 5mg for $70.00 at PrescriptionPoint compared to the max price for 90 of $70.00.
PrescriptionPoint Pharmacy is certified by
1 container (90): Visken 5mg
$70.00
Regular Shipping:
$9.95
Total:
$79.95
Go To Store

Visken Prices from MapleLeafMeds

Visken 5mg

90
Brand

$70.00

viewdetail

$ 0.78

Go To STORE
0.00%
When you buy 1 container of Visken 5mg for $70.00 at MapleLeafMeds compared to the max price for 90 of $70.00.
MapleLeafMeds Pharmacy is certified by
1 container (90): Visken 5mg
$70.00
Regular Shipping:
$9.95
Total:
$79.95
Go To Store

Visken Prices from DoctorSolve

Visken 5mg

90
Brand

$70.00

viewdetail

$ 0.78

Go To STORE
0.00%
When you buy 1 container of Visken 5mg for $70.00 at DoctorSolve compared to the max price for 90 of $70.00.
DoctorSolve Pharmacy is certified by
1 container (90): Visken 5mg
$70.00
Regular Shipping:
$9.95
Coupon Discount
$19.9875
Total:
$59.9625
Go To Store

Visken Prices from Canada Drugs

Visken 5mg

112 tablet
Brand

$88.78

viewdetail

$ 0.79

Go To STORE
0.00%
When you buy 1 container of Visken 5mg for $88.78 at Canada Drugs compared to the max price for 112 tablet of $88.78.
Canada Drugs Pharmacy is certified by
1 container (112 tablet): Visken 5mg
$88.78
Regular Shipping:
$0.00
Coupon Discount
$22.195
Total:
$66.585
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Visken Prices from JanDrugs

Visken 5mg

112 tablet
Brand

$88.78

viewdetail

$ 0.79

Go To STORE
0.00%
When you buy 1 container of Visken 5mg for $88.78 at JanDrugs compared to the max price for 112 tablet of $88.78.
JanDrugs Pharmacy is certified by
1 container (112 tablet): Visken 5mg
$88.78
Regular Shipping:
$0.00
Coupon Discount
$8.878
Total:
$79.902
Go To Store

Visken Prices from Canada Drugs

Visken 5mg

56 tablet
Brand

$46.89

viewdetail

$ 0.84

Go To STORE
0.00%
When you buy 1 container of Visken 5mg for $46.89 at Canada Drugs compared to the max price for 56 tablet of $46.89.
Canada Drugs Pharmacy is certified by
1 container (56 tablet): Visken 5mg
$46.89
Regular Shipping:
$0.00
Coupon Discount
$11.7225
Total:
$35.1675
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Visken Prices from JanDrugs

Visken 5mg

56 tablet
Brand

$46.89

viewdetail

$ 0.84

Go To STORE
0.00%
When you buy 1 container of Visken 5mg for $46.89 at JanDrugs compared to the max price for 56 tablet of $46.89.
JanDrugs Pharmacy is certified by
1 container (56 tablet): Visken 5mg
$46.89
Regular Shipping:
$0.00
Coupon Discount
$4.689
Total:
$42.201
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Visken Prices from BuyLow Drugs

Visken 5mg

100
Brand

$94.00

viewdetail

$ 0.94

Go To STORE
56.68%
When you buy 1 container of Visken 5mg for $94.00 at BuyLow Drugs compared to the max price for 100 of $217.00.
1 container (100): Visken 5mg
$94.00
Regular Shipping:
$0.00
Total:
$94
Go To Store

Visken Prices from Canada Drugs

Visken 10mg

100 tablet
Brand

$104.21

viewdetail

$ 1.04

Go To STORE
51.98%
When you buy 1 container of Visken 10mg for $104.21 at Canada Drugs compared to the max price for 100 tablet of $217.00.
Canada Drugs Pharmacy is certified by
1 container (100 tablet): Visken 10mg
$104.21
Regular Shipping:
$0.00
Coupon Discount
$26.0525
Total:
$78.1575
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Visken Prices from JanDrugs

Visken 10mg

100 tablet
Brand

$104.21

viewdetail

$ 1.04

Go To STORE
51.98%
When you buy 1 container of Visken 10mg for $104.21 at JanDrugs compared to the max price for 100 tablet of $217.00.
JanDrugs Pharmacy is certified by
1 container (100 tablet): Visken 10mg
$104.21
Regular Shipping:
$0.00
Coupon Discount
$10.421
Total:
$93.789
Go To Store

Visken Prices from JanDrugs

Visken 15mg

84 tablet
Brand

$115.26

viewdetail

$ 1.37

Go To STORE
0.00%
When you buy 1 container of Visken 15mg for $115.26 at JanDrugs compared to the max price for 84 tablet of $115.26.
JanDrugs Pharmacy is certified by
1 container (84 tablet): Visken 15mg
$115.26
Regular Shipping:
$0.00
Coupon Discount
$11.526
Total:
$103.734
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Visken Prices from Canada Drugs

Visken 15mg

84 tablet
Brand

$115.26

viewdetail

$ 1.37

Go To STORE
0.00%
When you buy 1 container of Visken 15mg for $115.26 at Canada Drugs compared to the max price for 84 tablet of $115.26.
Canada Drugs Pharmacy is certified by
1 container (84 tablet): Visken 15mg
$115.26
Regular Shipping:
$0.00
Coupon Discount
$28.815
Total:
$86.445
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Visken Prices from Online Pharmacies Canada

Visken 10mg

100
Brand

$144.26

viewdetail

$ 1.44

Go To STORE
33.52%
When you buy 1 container of Visken 10mg for $144.26 at Online Pharmacies Canada compared to the max price for 100 of $217.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (100): Visken 10mg
$144.26
Regular Shipping:
$9.95
Total:
$154.21
Go To Store

Visken Prices from Quality Prescription Drugs

Visken 10mg

100
Brand

$144.53

viewdetail

$ 1.45

Go To STORE
33.40%
When you buy 1 container of Visken 10mg for $144.53 at Quality Prescription Drugs compared to the max price for 100 of $217.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (100): Visken 10mg
$144.53
Regular Shipping:
$9.00
Total:
$153.53
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Visken Prices from Pharma Passport

Visken 10mg

100
Brand

$144.81

viewdetail

$ 1.45

Go To STORE
33.27%
When you buy 1 container of Visken 10mg for $144.81 at Pharma Passport compared to the max price for 100 of $217.00.
1 container (100): Visken 10mg
$144.81
Regular Shipping:
$9.95
Total:
$154.76
Go To Store

Visken Prices from MapleLeafMeds

Visken 10mg

100
Brand

$145.00

viewdetail

$ 1.45

Go To STORE
33.18%
When you buy 1 container of Visken 10mg for $145.00 at MapleLeafMeds compared to the max price for 100 of $217.00.
MapleLeafMeds Pharmacy is certified by
1 container (100): Visken 10mg
$145.00
Regular Shipping:
$9.95
Total:
$154.95
Go To Store

Visken Prices from DoctorSolve

Visken 10mg

100
Brand

$150.00

viewdetail

$ 1.50

Go To STORE
30.88%
When you buy 1 container of Visken 10mg for $150.00 at DoctorSolve compared to the max price for 100 of $217.00.
DoctorSolve Pharmacy is certified by
1 container (100): Visken 10mg
$150.00
Regular Shipping:
$9.95
Coupon Discount
$39.9875
Total:
$119.9625
Go To Store

Visken Prices from Online Canadian Pharmacy

Visken 10mg

100
Brand

$150.50

viewdetail

$ 1.51

Go To STORE
30.65%
When you buy 1 container of Visken 10mg for $150.50 at Online Canadian Pharmacy compared to the max price for 100 of $217.00.
1 container (100): Visken 10mg
$150.50
Regular Shipping:
$0.00
Total:
$150.5
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Visken Prices from BuyLow Drugs

Visken 10mg

100
Brand

$153.00

viewdetail

$ 1.53

Go To STORE
29.49%
When you buy 1 container of Visken 10mg for $153.00 at BuyLow Drugs compared to the max price for 100 of $217.00.
1 container (100): Visken 10mg
$153.00
Regular Shipping:
$0.00
Total:
$153
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Visken Prices from PrescriptionPoint

Visken 10mg

100
Brand

$155.00

viewdetail

$ 1.55

Go To STORE
28.57%
When you buy 1 container of Visken 10mg for $155.00 at PrescriptionPoint compared to the max price for 100 of $217.00.
PrescriptionPoint Pharmacy is certified by
1 container (100): Visken 10mg
$155.00
Regular Shipping:
$9.95
Total:
$164.95
Go To Store

Visken Prices from JanDrugs

Visken 15mg

28 tablet
Brand

$43.42

viewdetail

$ 1.55

Go To STORE
0.00%
When you buy 1 container of Visken 15mg for $43.42 at JanDrugs compared to the max price for 28 tablet of $43.42.
JanDrugs Pharmacy is certified by
1 container (28 tablet): Visken 15mg
$43.42
Regular Shipping:
$0.00
Coupon Discount
$4.342
Total:
$39.078
Go To Store

Visken Prices from Canada Drugs

Visken 15mg

28 tablet
Brand

$43.42

viewdetail

$ 1.55

Go To STORE
0.00%
When you buy 1 container of Visken 15mg for $43.42 at Canada Drugs compared to the max price for 28 tablet of $43.42.
Canada Drugs Pharmacy is certified by
1 container (28 tablet): Visken 15mg
$43.42
Regular Shipping:
$0.00
Coupon Discount
$10.855
Total:
$32.565
Go To Store

Visken Prices from Pharma Passport

Visken 15mg

100
Brand

$198.26

viewdetail

$ 1.98

Go To STORE
8.64%
When you buy 1 container of Visken 15mg for $198.26 at Pharma Passport compared to the max price for 100 of $217.00.
1 container (100): Visken 15mg
$198.26
Regular Shipping:
$9.95
Total:
$208.21
Go To Store

Visken Prices from Online Pharmacies Canada

Visken 15mg

100
Brand

$198.49

viewdetail

$ 1.98

Go To STORE
8.53%
When you buy 1 container of Visken 15mg for $198.49 at Online Pharmacies Canada compared to the max price for 100 of $217.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (100): Visken 15mg
$198.49
Regular Shipping:
$9.95
Total:
$208.44
Go To Store

Visken Prices from Quality Prescription Drugs

Visken 15mg

100
Brand

$198.87

viewdetail

$ 1.99

Go To STORE
8.35%
When you buy 1 container of Visken 15mg for $198.87 at Quality Prescription Drugs compared to the max price for 100 of $217.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (100): Visken 15mg
$198.87
Regular Shipping:
$9.00
Total:
$207.87
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Visken Prices from MapleLeafMeds

Visken 15mg

100
Brand

$200.00

viewdetail

$ 2.00

Go To STORE
7.83%
When you buy 1 container of Visken 15mg for $200.00 at MapleLeafMeds compared to the max price for 100 of $217.00.
MapleLeafMeds Pharmacy is certified by
1 container (100): Visken 15mg
$200.00
Regular Shipping:
$9.95
Total:
$209.95
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Visken Prices from Online Canadian Pharmacy

Visken 15mg

100
Brand

$203.17

viewdetail

$ 2.03

Go To STORE
6.37%
When you buy 1 container of Visken 15mg for $203.17 at Online Canadian Pharmacy compared to the max price for 100 of $217.00.
1 container (100): Visken 15mg
$203.17
Regular Shipping:
$0.00
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$203.17
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Visken Prices from PrescriptionPoint

Visken 15mg

100
Brand

$205.00

viewdetail

$ 2.05

Go To STORE
5.53%
When you buy 1 container of Visken 15mg for $205.00 at PrescriptionPoint compared to the max price for 100 of $217.00.
PrescriptionPoint Pharmacy is certified by
1 container (100): Visken 15mg
$205.00
Regular Shipping:
$9.95
Total:
$214.95
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Visken Prices from DoctorSolve

Visken 15mg

100
Brand

$206.00

viewdetail

$ 2.06

Go To STORE
5.07%
When you buy 1 container of Visken 15mg for $206.00 at DoctorSolve compared to the max price for 100 of $217.00.
DoctorSolve Pharmacy is certified by
1 container (100): Visken 15mg
$206.00
Regular Shipping:
$9.95
Coupon Discount
$53.9875
Total:
$161.9625
Go To Store

Visken Prices from BuyLow Drugs

Visken 15mg

100
Brand

$217.00

viewdetail

$ 2.17

Go To STORE
0.00%
When you buy 1 container of Visken 15mg for $217.00 at BuyLow Drugs compared to the max price for 100 of $217.00.
1 container (100): Visken 15mg
$217.00
Regular Shipping:
$0.00
Total:
$217
Go To Store

Visken Information

Company Name
Novartis Pharmaceuticals Corporation

Visken ()

Visken () Description

Visken () (pindolol), a synthetic beta-adrenergic receptor blocking agent with intrinsic sympathomimetic activity is 1-(Indol-4-yloxy)-3-(isopropylamino)-2-propanol.

Its structural formula is:

Pindolol is a white to off-white odorless powder soluble in organic solvents and aqueous acids. Visken () (pindolol) is intended for oral administration.

Visken () Clinical Pharmacology

Visken ()  (pindolol) is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity.

Visken () Pharmacodynamics

In standard pharmacologic tests in man and animals, Visken () (pindolol) attenuates increases in heart rate, systolic blood pressure, and cardiac output resulting from exercise and isoproterenol administration, thus confirming its beta-blocking properties. The ISA or partial agonist activity of Visken () (pindolol) is mediated directly at the adrenergic receptor sites and may be blocked by other beta-blockers. In catecholamine-depleted animal experiments, ISA is manifested as an increase in the inotropic and chronotropic activity of the myocardium. In man, ISA is manifested by a smaller reduction in the resting heart rate (4-8 beats/min) than is seen with drugs lacking ISA. There is also a smaller reduction in resting cardiac output. The clinical significance of this observation has not been evaluated and there is no evidence, or reason to believe, that exercise cardiac output is less affected by Visken () (pindolol).

Visken () (pindolol) has been shown in controlled, double-blind clinical studies to be an effective antihypertensive agent when used as monotherapy, or when added to therapy with thiazide-type diuretics. Divided dosages in the range of 10-60 mg daily have been shown to be effective. As monotherapy, Visken () (pindolol) is as effective as propranolol, α-methyldopa, hydrochlorothiazide, and chlorthalidone in reducing systolic and diastolic blood pressure. The effect on blood pressure is not orthostatic, i.e. Visken () (pindolol) was equally effective in reducing the supine and standing blood pressure.

In open, long-term studies up to 4 years, no evidence of diminution of the blood pressure-lowering response was observed.

An average 3-pound increase in body weight has been noted in patients treated with Visken () (pindolol) alone, a larger increase than was observed with propranolol or placebo. The weight gain appeared unrelated to blood pressure response and was not associated with an increased risk of heart failure, although edema was more common than in control patients. Visken () (pindolol) does not have a consistent effect on plasma renin activity.

The mechanism of the antihypertensive effects of beta-blocking agents has not been established, but several mechanisms have been postulated: 1) an effect on the central nervous system resulting in a reduced sympathetic outflow to the periphery, 2) competitive antagonism of catecholamines at peripheral (especially cardiac) adrenergic receptor sites, leading to decreased cardiac output, 3) an inhibition of renin release. These mechanisms appear less likely for pindolol than other beta-blockers in view of the modest effect on resting cardiac output and renin.

Beta-blockade therapy is useful when it is necessary to suppress the effects of beta-adrenergic agonists in order to achieve therapeutic goals. However, in certain clinical situations, (e.g., cardiac failure, heart block, bronchospasm), the preservation of an adequate sympathetic tone may be necessary to maintain vital functions. Although a beta-antagonist with ISA such as Visken () (pindolol) does not eliminate sympathetic tone entirely, there is no controlled evidence that it is safer than other beta-blockers in such conditions as heart failure, heart block, or bronchospasm or is less likely to cause those conditions. In single dose studies of the effects of beta-blockers on FEV, Visken () (pindolol) was indistinguishable from other non-cardioselective agents in its reduction of FEV, and its reduction in the effectiveness of an exogenous beta agonist.

Exacerbation of angina and, in some cases, myocardial infarction and ventricular dysrhythmias have been reported after abrupt discontinuation of therapy with beta-adrenergic blocking agents in patients with coronary artery disease. Abrupt withdrawal of these agents in patients without coronary artery disease has resulted in transient symptoms, including tremulousness, sweating, palpitation, headache, and malaise. Several mechanisms have been proposed to explain these phenomena, among them increased sensitivity to catecholamines because of increased numbers of beta receptors.

Visken () Pharmacokinetics And Metabolism

Visken () (pindolol) is rapidly and reproducibly absorbed (greater than 95%), achieving peak plasma concentrations within 1 hour of drug administration. Visken () (pindolol) has no significant first-pass effect. The blood concentrations are proportional in a linear manner to the administered dose in the range of 5-20 mg. Upon repeated administration to the same subject, variation is minimal. After a single dose, intersubject variation for peak plasma concentrations was about 4fold (e.g., 45-167 ng/mL for a 20 mg dose). Upon multiple dosing, intersubject variation decreased to 2-2.5 fold. Visken () (pindolol) is only 40% bound to plasma proteins and is evenly distributed between plasma and red cells. The volume of distribution in healthy subjects is about 2 L/kg.

Visken () (pindolol) undergoes extensive metabolism in animals and man. In man, 35%-40% is excreted unchanged in the urine and 60%-65% is metabolized primarily to hydroxy-metabolites which are excreted as glucuronides and ethereal sulfates. The polar metabolites are excreted with a half-life of approximately 8 hours and thus multiple dosing therapy (q.8H) results in a less than 50% accumulation in plasma. About 6%-9% of an administered intravenous dose is excreted by the bile into the feces.

The disposition of Visken () (pindolol) after oral administration is monophasic with a half-life in healthy subjects or hypertensive patients with normal renal function of approximately 3-4 hours. Following t.i.d. administration (q.8H), no significant accumulation of Visken () (pindolol) is observed.

In elderly hypertensive patients with normal renal function, the half-life of Visken () (pindolol) is more variable, averaging about 7 hours, but with values as high as 15 hours.

In hypertensive patients with renal diseases, the half-life is within the range expected for healthy subjects. However, a significant decrease (50%) in volume of distribution (V) is observed in uremic patients and V appears to be directly correlated to creatinine clearance. Therefore, renal drug clearance is significantly reduced in uremic patients, resulting in a significant decrease in urinary excretion of unchanged drug. Uremic patients with a creatinine clearance of less than 20 mL/min generally excreted less than 15% of the administered dose unchanged in the urine.

In patients with histologically diagnosed cirrhosis of the liver, the elimination of Visken () (pindolol) was more variable in rate and generally significantly slower than in healthy subjects. The total body clearance of Visken () (pindolol) in cirrhotic patients ranged from about 50-300 mL/min and was directly correlated to antipyrine clearance. The half-life ranges from 2.5 hours to greater than 30 hours. These findings strongly suggest that caution should be exercised in dosage adjustments of Visken () (pindolol) in such patients.

The bioavailability of Visken () (pindolol) is not significantly affected by co-administration of food, hydralazine, hydrochlorothiazide or aspirin. Visken () (pindolol) has no effect on warfarin activity or the clinical effectiveness of digoxin, although small transient decreases in plasma digoxin concentrations were noted.

Visken () Indications And Usage

Visken () (pindolol) is indicated in the management of hypertension. It may be used alone or concomitantly with other antihypertensive agents, particularly with a thiazide-type diuretic.

Visken () Contraindications

Visken () (pindolol) is contraindicated in: 1) bronchial asthma; 2) overt cardiac failure; 3) cardiogenic shock; 4) second and third degree heart block; 5) severe bradycardia.

Visken () Warnings

Sympathetic stimulation may be a vital component supporting circulatory function in patients with congestive heart failure, and its inhibition by beta-blockade may precipitate more severe failure. Although beta-blockers should be avoided in overt congestive heart failure, if necessary, Visken () (pindolol) can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. Beta-adrenergic blocking agents do not abolish the inotropic action of digitalis on heart muscle.

In patients with latent cardiac insufficiency, continued depression of the myocardium with beta-blocking agents over a period of time can in some cases lead to cardiac failure. At the first sign or symptom of impending cardiac failure, patients should be fully digitalized and/or be given a diuretic, and the response observed closely. If cardiac failure continues, despite adequate digitalization and diuretic, Visken () (pindolol) therapy should be withdrawn (gradually if possible).

Visken () (pindolol) should be administered with caution since it may block bronchodilation produced by endogenous or exogenous catecholamine stimulation of beta receptors.

Because beta blockade impairs the ability of the heart to respond to reflex stimuli and may increase the risks of general anesthesia and surgical procedures, resulting in protracted hypotension or low cardiac output, it has generally been suggested that such therapy should be gradually withdrawn several days prior to surgery. Recognition of the increased sensitivity to catecholamines of patients recently withdrawn from beta-blocker therapy, however, has made this recommendation controversial. If possible, beta-blockers should be withdrawn well before surgery takes place. In the event of emergency surgery, the anesthesiologist should be informed that the patient is on beta-blocker therapy.

The effects of Visken () (pindolol) can be reversed by administration of beta-receptor agonists such as isoproterenol, dopamine, dobutamine, or levarterenol. Difficulty in restarting and maintaining the heart beat has also been reported with beta-adrenergic receptor blocking agents.

Beta-adrenergic blockade may prevent the appearance of premonitory signs and symptoms (e.g., tachycardia and blood pressure changes) of acute hypoglycemia. This is especially important with labile diabetics. Beta-blockade also reduces the release of insulin in response to hyperglycemia; therefore, it may be necessary to adjust the dose of antidiabetic drugs.

Beta-adrenergic blockade may mask certain clinical signs (e.g., tachycardia) of hyperthyroidism. Patients suspected of developing thyrotoxicosis should be managed carefully to avoid abrupt withdrawal of beta-blockade which might precipitate a thyroid crisis.

Visken () Precautions

Beta-blocking agents should be used with caution in patients with impaired hepatic or renal function. Poor renal function has only minor effects on Visken () (pindolol) clearance, but poor hepatic function may cause blood levels of Visken () (pindolol) to increase substantially.

Patients, especially those with evidence of coronary artery insufficiency, should be warned against interruption or discontinuation of Visken () (pindolol) therapy without the physician’s advice. Although cardiac failure rarely occurs in properly selected patients, patients being treated with beta-adrenergic blocking agents should be advised to consult the physician at the first sign or symptom of impending failure.

Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients receiving Visken () (pindolol) plus a catecholamine-depleting agent should, therefore, be closely observed for evidence of hypotension and/or marked bradycardia which may produce vertigo, syncope, or postural hypotension.

Visken () (pindolol) has been used with a variety of antihypertensive agents, including hydrochlorothiazide, hydralazine, and guanethidine without unexpected adverse interactions.

Visken () (pindolol) has been shown to increase serum thioridazine levels when both drugs are co-administered. Visken () (pindolol) levels may also be increased with this combination.

In chronic oral toxicologic studies (1-2 years) in mice, rats, and dogs, Visken () (pindolol) did not produce any significant toxic effects. In 2-year oral carcinogenicity studies in rats and mice in doses as high as 59 mg/kg/day and 124 mg/kg/day (50 and 100 times the maximum recommended human dose), respectively, Visken () (pindolol) did not produce any neoplastic, preneoplastic, or nonneoplastic pathologic lesions. In fertility and general reproductive performance studies in rats, Visken () (pindolol) caused no adverse effects at a dose of 10 mg/kg.

In the male fertility and general reproductive performance test in rats, definite toxicity characterized by mortality and decreased weight gain was observed in the group given 100 mg/kg/day. At 30 mg/kg/day, decreased mating was associated with testicular atrophy and/or decreased spermatogenesis. This response is not clearly drug related, however, as there was no dose response relationship within this experiment and no similar effect on testes of rats administered Visken () (pindolol) as a dietary admixture for 104 weeks. There appeared to be an increase in prenatal mortality in males given 100 mg/kg but development of offspring was not impaired.

In females administered Visken () (pindolol) prior to mating through day 21 of lactation, mating behavior was decreased at 100 mg/kg and 30 mg/kg. At these dosages there also was increased mortality of offspring. Prenatal mortality was increased at 10 mg/kg but there was not a clear dose response relationship in this experiment. There was an increased resorption rate at 100 mg/kg observed in females necropsied on the 15th day of gestation.

Visken () Clinical Laboratory

Minor persistent elevations in serum transaminases (SGOT, SGPT) have been noted in 7% of patients during Visken () (pindolol) administration, but progressive elevations were not observed. These elevations were not associated with any other abnormalities that would suggest hepatic impairment, such as decreased serum albumin and total proteins. During more than a decade of worldwide marketing, there have been no reports in the medical literature of overt hepatic injury. Alkaline phosphatase, lactic acid dehydrogenase (LDH), and uric acid are also elevated on rare occasions. The significance of these findings is unknown.

Visken () Adverse Reactions

Most adverse reactions have been mild. The incidences listed in the following table are derived from 12-week comparative double-blind, parallel design trials in hypertensive patients given Visken () (pindolol) as monotherapy, given various active control drugs as monotherapy, or given placebo. Data for Visken () (pindolol) and the positive controls were pooled from several trials because no striking differences were seen in the individual studies, with 1 exception. When considering all adverse reactions reported, the frequency of edema was noticeably higher in positive control trials [16% Visken () (pindolol) vs. 9% positive control] than in placebo controlled trials [6%Visken () (pindolol) vs. 3% placebo]. The table includes adverse reactions either volunteered or elicited, and at least possibly drug related, which were reported in greater than 2% of Visken () (pindolol) patients and other selected important reactions.

The following selected (potentially important) adverse reactions were seen in 2% or fewer patients and their relationship to Visken () (pindolol) is uncertain. CENTRAL NERVOUS SYSTEM: anxiety, lethargy; AUTONOMIC NERVOUS SYSTEM: visual disturbances, hyperhidrosis; CARDIOVASCULAR: bradycardia, claudication, cold extremities, heart block, hypotension, syncope, tachycardia, weight gain; GASTROINTESTINAL: diarrhea, vomiting; RESPIRATORY: wheezing; UROGENITAL: impotence, pollakiuria; MISCELLANEOUS: eye discomfort or burning eyes.

Visken () Potential Adverse Effects

In addition, other adverse effects not aforementioned have been reported with other beta-adrenergic blocking agents and should be considered potential adverse effects of Visken () (pindolol).

The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with Visken () (pindolol) during investigational use and extensive foreign experience amounting to over 4 million patient-years.

Visken () Overdosage

No specific information on emergency treatment of overdosage is available. Therefore, on the basis of the pharmacologic actions of Visken () (pindolol), the following general measures should be employed as appropriate in addition to gastric lavage:

A case of an acute overdosage has been reported with an intake of 500 mg of Visken () (pindolol) by a hypertensive patient. Blood pressure increased and heart rate was ≥80 beats/min. Recovery was uneventful. In another case, 250 mg of Visken () (pindolol) was taken with 150 mg diazepam and 50 mg nitrazepam, producing coma and hypotension. The patient recovered in 24 hours.

Visken () Dosage And Administration

The dosage of Visken () (pindolol) should be individualized. The recommended initial dose of Visken () (pindolol) is 5 mg b.i.d. alone or in combination with other antihypertensive agents. An antihypertensive response usually occurs within the first week of treatment. Maximal response, however, may take as long as or occasionally longer than 2 weeks. If a satisfactory reduction in blood pressure does not occur within 3-4 weeks, the dose may be adjusted in increments of 10 mg/day at these intervals up to a maximum of 60 mg/day.

Visken () How Supplied

Below 86°F (30°C); tight, light-resistant container.

Manufactured by:

Novartis Pharmaceuticals Canada Inc.

Dorval (Quebec) Canada H9R 4P5

Distributed by:

Novartis Pharmaceuticals Corporation

East Hanover, New Jersey 07936

REV: NOVEMBER 1998                         T1999-39

89003701

2162-25-99A

©1998 Novartis

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