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Podofilox Price Comparison

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Podofilox Prices from CanadianPharmacyKing

Podofilox 0.5 %/3.5 ml

1
Brand

$67.00

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$ 67.00

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0.00%
When you buy 1 container of Podofilox 0.5 %/3.5 ml for $67.00 at CanadianPharmacyKing compared to the max price for 1 of $67.00.
CanadianPharmacyKing Pharmacy is certified by
1 container (1): Podofilox 0.5 %/3.5 ml
$67.00
Regular Shipping:
$10.00
Total:
$77
Go To Store

Podofilox Prices from Big Mountain Drugs

Podofilox 0.5 %/3.5 ml

1
Brand

$67.00

viewdetail

$ 67.00

Go To STORE
0.00%
When you buy 1 container of Podofilox 0.5 %/3.5 ml for $67.00 at Big Mountain Drugs compared to the max price for 1 of $67.00.
1 container (1): Podofilox 0.5 %/3.5 ml
$67.00
Regular Shipping:
$10.00
Coupon Discount
$7.7
Total:
$69.3
Go To Store

Podofilox Information

Product Code
0574-0611
Company Name
Watson Laboratories, Inc.
Dosage From
SOLUTION
Strength
5 mg
Active Ingredient
PODOFILOX

Podofilox (Podofilox) Description

Podofilox (Podofilox) Topical Solution is an antimitotic drug which can be chemically synthesized or purified from the plant families and (e.g. species of and ). Podofilox (Podofilox) Topical Solution 0.5% is formulated for topical administration. Each milliliter of solution contains 5 mg of Podofilox (Podofilox) , in a vehicle containing lactic acid and sodium lactate in alcohol 95%, USP.

Podofilox (Podofilox) has a molecular weight of 414.4 daltons, and is soluble in alcohol and sparingly soluble in water. Its chemical name is 5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxylphenyl)furo[3',4':6,7] naphtho[2,3,d]-1, 3-dioxol-6(5aH)-one. Podofilox (Podofilox) has the following structural formula:

Podofilox (Podofilox) Clinical Studies

In clinical studies with Podofilox (Podofilox) solution, the test product and its vehicle were applied in a double-blind fashion to comparable patient groups. Patients were treated for two to four weeks, and reevaluated at a two-week follow-up examination. Although the number of patients and warts evaluated at each time period varied, the results among investigators were relatively consistent.

The following table represents the responses noted in terms of frequency of response by lesions treated and the overall response by patients. Data are presented for the 2-week follow-up only for those patients evaluated at that time point.

Podofilox (Podofilox) Indications And Usage

Podofilox (Podofilox) Topical Solution 0.5% is indicated for the topical treatment of external genital warts (Condyloma acuminatum). This product is indicated in the treatment of perianal or mucous membrane warts (see ).

Podofilox (Podofilox) Contraindications

Podofilox (Podofilox) Topical Solution 0.5% is contraindicated for patients who develop hypersensitivity or intolerance to any component of the formulation.

Podofilox (Podofilox) Warnings

Correct diagnosis of the lesions to be treated is essential. See the subsection of the statement.

Podofilox (Podofilox) Topical Solution 0.5% is intended for cutaneous use only.

Podofilox (Podofilox) Precautions

Reports of lifetime carcinogenicity studies in mice are not available. Published animal studies, in general, have not shown the drug substance, Podofilox (Podofilox) , to be carcinogenic. There are published reports that, in mouse studies, crude podophyllin resin (containing Podofilox (Podofilox) ) applied topically to the cervix produced changes resembling carcinoma . These changes were reversible at five weeks after cessation of treatment. In one reported experiment, epidermal carcinoma of the vagina and cervix was found in 1 out of 18 mice after 120 applications of podophyllin (the drug was applied twice weekly over a 15-month period).

Podofilox (Podofilox) was not mutagenic in the Ames plate reverse mutation assay at concentrations up to 5 mg/plate, with and without metabolic activation. No cell transformation related to potential oncogenicity was observed in BALB/3T3 cells after exposure to Podofilox (Podofilox) at concentrations up to 0.008 µg/mL without metabolic activation and 12 µg/mL Podofilox (Podofilox) with metabolic activation. Results from the mouse micronucleus assay using Podofilox (Podofilox) 0.5% solution in concentrations up to 25 mg/kg, indicate that Podofilox (Podofilox) should be considered a potential clastogen (a chemical that induces disruption and breakage of chromosomes).

Daily topical application of Podofilox (Podofilox) Topical Solution 0.5% at doses up to the equivalent of 0.2 mg/kg (5 times the recommended maximum human dose) to rats throughout gametogenesis, mating, gestation, parturition and lactation for two generations demonstrated no impairment of fertility.

Podofilox (Podofilox) Adverse Reactions

In clinical trials, the following local adverse reactions were reported at some point during treatment.

Reports of burning and pain were more frequent and of greater severity in women than in men.

Adverse effects reported in less than 5% of the patients included pain with intercourse, insomnia, tingling, bleeding, tenderness, chafing, malodor, dizziness, scarring, vesicle formation, crusting edema, dryness/peeling, foreskin irretraction, hematuria, vomiting and ulceration.

Podofilox (Podofilox) Overdose

Topically applied Podofilox (Podofilox) may be absorbed systemically (see section). Toxicity reported following systemic administration of Podofilox (Podofilox) in investigational use for cancer treatment included: nausea, vomiting, fever, diarrhea, bone marrow depression, and oral ulcers. Following 5 to 10 daily intravenous doses of 0.5 to 1 mg/kg/day, significant hematological toxicity occurred but was reversible. Other toxicities occurred at lower doses. Toxicity reported following systemic administration of podophyllum resin included: nausea, vomiting, fever, diarrhea, peripheral neuropathy, altered mental status, lethargy, coma, tachypnea, respiratory failure, leukocytosis, pancytosis, hematuria, renal failure, and seizures. Treatment of topical overdosage should include washing the skin free of any remaining drug and symptomatic and supportive therapy.

Podofilox (Podofilox) Dosage And Administration

In order to ensure that the patient is fully aware of the correct method of therapy and to identify which specific warts should be treated, the technique for initial application of the medication should be demonstrated by the prescriber.

Apply twice daily morning and evening (every 12 hours), for 3 consecutive days, then withhold use for 4 consecutive days. This one week cycle of treatment may be repeated up to four times until there is no visible wart tissue.

Podofilox (Podofilox) Topical Solution 0.5% is applied to the warts with an applicator supplied with the drug. The drug-dampened applicator should be touched to the wart to be treated, applying the minimum amount of solution necessary to cover the lesion. There is no evidence to suggest that more frequent application will increase efficacy, but additional applications would be expected to increase the rate of local adverse reactions and systemic absorption.

Care should be taken to allow the solution to dry before allowing the return of opposing skin surfaces to their normal positions. After each treatment, the used applicator should be carefully disposed of and the patient should wash his or her hands.

Podofilox (Podofilox) How Supplied

3.5 mL Podofilox (Podofilox) Topical Solution 0.5% is supplied as a clear liquid in amber glass bottles with child-resistant screw caps. NDC 0574-0611-05. Store at 20° and 25°C (68° to 77°F) [see USP Controlled Room Temperature].

Podofilox (Podofilox)

Podofilox (Podofilox) Patient Information

Podofilox (Podofilox) Topical Solution slowly kills external genital warts. The warts will change from a fleshy skin color to a dry, crusted, dead look, then disappear. Three out of four patients feel some burning or pain after they apply Podofilox (Podofilox) Topical Solution. Other side effects may include redness, soreness, tenderness, and small sores. These usually go away within a week after Podofilox (Podofilox) Topical Solution is stopped. If pain or other side effects bother you too much, stop applying Podofilox (Podofilox) Topical Solution and contact your doctor.

Follow these and your doctor's instructions carefully. Apply Podofilox (Podofilox) Topical Solution only on the warts pointed out by your doctor. Do not use it on any other warts on or inside your body, or for any other skin growth.

(08-05)

Podofilox (Podofilox) Principal Display Panel - . Ml Bottle Label

NDC 0574-0611-05

3.5 mL

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