Mebendazole Information
Mebendazole () Description
Mebendazole () is a (synthetic) broad-spectrum anthelmintic available as chewable tablets, each containing 100 mg of Mebendazole () . Inactive ingredients are: anhydrous lactose NF, corn starch, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, sodium saccharin, sodium starch glycolate, stearic acid, and FD&C Yellow #6.
Mebendazole () is methyl 5-benzoylbenzimidazole-2-carbamate and has the following structural formula:
Molecular Formula: CHNO
Mebendazole () is a white to slightly yellow powder with a molecular weight of 295.29. It is less than 0.05% soluble in water, dilute mineral acid solutions, alcohol, ether and chloroform, but is soluble in formic acid.
Mebendazole () Clinical Pharmacology
Following administration of 100 mg twice daily for three consecutive days, plasma levels of Mebendazole () and its primary metabolite, the 2-amine, do not exceed 0.03 mcg/mL and 0.09 mcg/mL, respectively. All metabolites are devoid of anthelmintic activity. In man, approximately 2% of administered Mebendazole () is excreted in urine and the remainder in the feces as unchanged drug or a primary metabolite.
Mebendazole () Indications And Usage
Mebendazole () tablets are indicated for the treatment of (pinworm), (whipworm), (common roundworm), (common hookworm), (American hookworm) in single or mixed infections.
Efficacy varies as a function of such factors as preexisting diarrhea and gastrointestinal transit time, degree of infection, and helminth strains. Efficacy rates derived from various studies are shown in the table below:
Mebendazole () Contraindications
Mebendazole () is contraindicated in persons who have shown hypersensitivity to the drug.
Mebendazole () Warnings
There is no evidence that Mebendazole () , even at high doses, is effective for hydatid disease. There have been rare reports of neutropenia and agranulocytosis when Mebendazole () was taken for prolonged periods and at dosages substantially above those recommended.
Mebendazole () Precautions
Periodic assessment of organ system functions, including hematopoietic and hepatic, is advisable during prolonged therapy.
Patients should be informed of the potential risk to the fetus in women taking Mebendazole () during pregnancy, especially during the first trimester (See ).
Patients should also be informed that cleanliness is important to prevent reinfection and transmission of the infection.
Mebendazole () Overdosage
In the event of accidental overdosage, gastrointestinal complaints lasting up to a few hours may occur. Vomiting and purging should be induced.
Mebendazole () Dosage And Administration
The same dosage schedule applies to children and adults. The tablet may be chewed, swallowed, or crushed and mixed with food.
If the patient is not cured three weeks after treatment, a second course of treatment is advised. No special procedures, such as fasting or purging, are required.
Mebendazole () How Supplied
Mebendazole () 100 mg, chewable, round, light peach-colored, unscored tablets, debossed “93” and “107” on one side and plain on the other side, supplied in boxes of twelve tablets, blister packaged.
Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].
Mebendazole () Mebendazole Tablets, Usp
Your doctor has prescribed this medicine to treat an infection caused by an intestinal worm. Follow your doctor’s instructions carefully. In addition to your doctor’s treatment, you can help prevent reinfection and infection of other people by understanding a few simple facts about worms.
The eggs, which are too small to see, contaminate whatever they come in contact with: bedclothes, underwear, hands, and food touched by contaminated hands. Even eggs floating in the air can be swallowed and cause infection. Pinworms are highly contagious. Even the cleanest and most careful people can get them.
Eggs from the worms are deposited in the soil if an infected person fails to use a toilet or bathroom. Since the eggs can live only in warm soil, they are found most often where the soil never freezes in winter. People living or traveling in areas with warm winters may have these infections. The eggs in the soil are usually carried to the mouth on food or by contact with dirty hands. In the case of hookworms a pre-adult form of the worm actually penetrates the skin (usually the foot) and burrows its way into the bloodstream. Once inside the body, they grow and breed inside the bowel. New eggs are released in the feces.
Therefore, poor sewage disposal or the use of human waste for fertilizer can contaminate the ground with new eggs, which can then reinfect people.
The medication used to treat these worms causes them to be expelled from the body. Hookworms and whipworms may be seen and resemble small white threads. Roundworms are much larger and easily seen.
Follow your doctor’s advice, take the medication he gives you and follow the rules mentioned here. If you have other questions about worms, be sure to ask your doctor.
Manufactured By:
Sellersville, PA 18960
Rev. D 9/2007
Mebendazole ()
Mebendazole ()
