Glycopyrrolate Information
Glycopyrrolate ()
Glycopyrrolate () Description
Glycopyrrolate () Tablets contain the synthetic anticholinergic, Glycopyrrolate () . Glycopyrrolate () is a quaternary ammonium compound with the following chemical name: 3-[(cyclopentylhydroxyacetyl)oxy]-1,1-dimethylpyrrolidinium bromide. are White, Round Tablets; Debossed "WW" on the top of the score and "15" under score, plain on the other side. Each tablet contains:Glycopyrrolate () , USP………..1 mg are White, Round Tablets; Debossed "WW" on top of score and "16" under score, plain on the other side. Each tablet contains:Glycopyrrolate () , USP……….2 mg : Dibasic Calcium Phosphate, Lactose Anhydrous, Lactose Monohydrate, Magnesium Stearate, Polyvinylpyrrolidone, Sodium Starch Glycolate.
Glycopyrrolate () Clinical Pharmacology
Glycopyrrolate () , like other anticholinergic (antimuscarinic) agents, inhibits the action of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of smooth muscle, cardiac muscle, the sino-atrial node, the atrioventricular node, exocrine glands, and, to a limited degree, in the autonomic ganglia. Thus, it diminishes the volume and free acidity of gastric secretions and controls excessive pharyngeal, tracheal, and bronchial secretions. Glycopyrrolate () antagonizes muscarinic symptoms (e.g., bronchorrhea, bronchospasm, bradycardia, and intestinal hypermotility) induced by cholinergic drugs such as the anticholinesterases. The highly polar quaternary ammonium group of Glycopyrrolate () limits its passage across lipid membranes, such as the blood-brain barrier, in contrast to atropine sulfate and scopolamine hydrobromide, which are non-polar tertiary amines which penetrate lipid barriers easily.
Glycopyrrolate () Indications And Usage
For use as adjunctive therapy in the treatment of peptic ulcer.
Glycopyrrolate () Contraindications
Glaucoma; obstructive uropathy (for example, bladder neck obstruction due to prostatic hypertrophy); obstructive disease of the gastrointestinal tract (as in achalasia, pyloroduodenal stenosis, etc.); paralytic ileus; intestinal atony of the elderly or debilitated patient; unstable cardiovascular status in acute hemorrhage; severe ulcerative colitis; toxic megacolon complicating ulcerative colitis; myasthenia gravis. Glycopyrrolate () Tablets are contraindicated in those patients with a hypersensitivity to Glycopyrrolate () .
Glycopyrrolate () Warnings
In the presence of a high environmental temperature, heat prostration (fever and heat stroke due to decreased sweating) can occur with the use of Glycopyrrolate () Tablets. Diarrhea may be an early symptom of incomplete intestinal obstruction, especially in patients with ileostomy or colostomy. In this instance treatment with this drug would be inappropriate and possibly harmful. Glycopyrrolate () Tablets may produce drowsiness or blurred vision. In this event, the patient should be warned not to engage in activities requiring mental alertness such as operating a motor vehicle or other machinery, or performing hazardous work while taking this drug. Theoretically, with overdosage, a curare-like action may occur, i.e., neuro-muscular blockade leading to muscular weakness and possible paralysis.
Glycopyrrolate () Precautions
Use Glycopyrrolate () Tablets with caution in the elderly and in all patients with:
Glycopyrrolate () Adverse Reactions
Anticholinergics produce certain effects, most of which are extensions of their fundamental pharmacological actions. Adverse reactions to anticholinergics in general may include xerostomia; decreased sweating; urinary hesitancy and retention; blurred vision; tachycardia; palpitations; dilatation of the pupil; cycloplegia; increased ocular tension; loss of taste; headaches; nervousness; mental confusion; drowsiness; weakness; dizziness; insomnia; nausea; vomiting; constipation; bloated feeling; impotence; suppression of lactation; severe allergic reaction or drug idiosyncrasies including anaphylaxis, urticaria and other dermal manifestations. Glycopyrrolate () Tablets is chemically a quaternary ammonium compound; hence, its passage across lipid membranes, such as the blood-brain barrier, is limited in contrast to atropine sulfate and scopolamine hydrobromide. For this reason the occurrence of CNS related side effects is lower, in comparison to their incidence following administration of anticholinergics which are chemically tertiary amines that can cross this barrier readily.
To report SUSPECTED ADVERSE REACTIONS, contact West-ward Pharmaceutical Corp. at 1-877-233-2001 or the FDA at 1-800-FDA-1088 or .
Glycopyrrolate () Overdosage
The symptoms of overdosage of Glycopyrrolate () are peripheral in nature rather than central.
Glycopyrrolate () Drug Interactions
There are no known drug interactions.
Glycopyrrolate () How Supplied
Glycopyrrolate () Tablets are available in the following strengths and package sizes:
Glycopyrrolate () Tablets USP, 1 mg - White, Round Tablet; Debossed "WW" on the top of the score and "15" under score, plain on the other side.
Bottles of 100 Tablets
Glycopyrrolate () Tablets USP, 2 mg - White, Round Tablet; Debossed "WW" on top of score and "16" under score, plain on the other side.
Bottles of 100 Tablets Manufactured By: Eatontown, NJ 0772Issued May 2010
Glycopyrrolate () Principal Display Panel
Glycopyrrolate () Tablets, USP1 mgNDC 0143-1250-01
Glycopyrrolate () Principal Display Panel
Glycopyrrolate () Tablets, USP2 mgNDC 0143-1251-01
