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You are here:Home»Prescription Drugs A to Z»Glipizide

Glipizide Price Comparison

Buy Glipizide Online and Read Glipizide Reviews

Use eDrugSearch to check Glipizide price comparison results below and read verified Glipizide reviews before you buy Glipizide online. Simply click the "Buy Now" button or the "Pharmacy Logo" to buy Glipizide online from one of our licensed Canadian pharmacies.

*To refine your Glipizide price comparison search further click on the "All, Brand or Generic" tab so you can view all the Glipizide prices located within our database.

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Glipizide Prices from Canada Drug Center

Glipizide 5mg

100
Generic

$29.00

viewdetail

$ 0.29

Go To STORE
57.35%
When you buy 1 container of Glipizide 5mg for $29.00 at Canada Drug Center compared to the max price for 100 of $68.00.
Canada Drug Center Pharmacy is certified by
1 container (100): Glipizide 5mg
$29.00
Regular Shipping:
$9.99
Coupon Discount
$3.899
Total:
$35.091
Go To Store

Glipizide Prices from Canadian Pharmacy Meds

Glipizide 5mg

100
Generic

$30.00

viewdetail

$ 0.30

Go To STORE
55.88%
When you buy 1 container of Glipizide 5mg for $30.00 at Canadian Pharmacy Meds compared to the max price for 100 of $68.00.
Canadian Pharmacy Meds Pharmacy is certified by
1 container (100): Glipizide 5mg
$30.00
Regular Shipping:
$10.00
Coupon Discount
$4
Total:
$36
Go To Store

Glipizide Prices from Canada Drug Pharmacy

Glipizide 5mg

100
Generic

$31.00

viewdetail

$ 0.31

Go To STORE
54.41%
When you buy 1 container of Glipizide 5mg for $31.00 at Canada Drug Pharmacy compared to the max price for 100 of $68.00.
Canada Drug Pharmacy Pharmacy is certified by
1 container (100): Glipizide 5mg
$31.00
Regular Shipping:
$9.99
Coupon Discount
$4.099
Total:
$36.891
Go To Store

Glipizide Prices from Online Canadian Pharmacy

Glipizide Xl 5mg

90
Generic

$32.39

viewdetail

$ 0.36

Go To STORE
53.06%
When you buy 1 container of Glipizide Xl 5mg for $32.39 at Online Canadian Pharmacy compared to the max price for 90 of $69.00.
1 container (90): Glipizide Xl 5mg
$32.39
Regular Shipping:
$0.00
Total:
$32.39
Go To Store

Glipizide Prices from PrescriptionPoint

Glipizide 5mg

90
Generic

$32.72

viewdetail

$ 0.36

Go To STORE
52.58%
When you buy 1 container of Glipizide 5mg for $32.72 at PrescriptionPoint compared to the max price for 90 of $69.00.
PrescriptionPoint Pharmacy is certified by
1 container (90): Glipizide 5mg
$32.72
Regular Shipping:
$9.95
Total:
$42.67
Go To Store

Glipizide Prices from DoctorSolve

Glipizide Xl 5mg

90
Generic

$32.72

viewdetail

$ 0.36

Go To STORE
52.58%
When you buy 1 container of Glipizide Xl 5mg for $32.72 at DoctorSolve compared to the max price for 90 of $69.00.
DoctorSolve Pharmacy is certified by
1 container (90): Glipizide Xl 5mg
$32.72
Regular Shipping:
$9.95
Coupon Discount
$10.6675
Total:
$32.0025
Go To Store

Glipizide Prices from DoctorSolve

Glipizide 5mg

90
Generic

$32.72

viewdetail

$ 0.36

Go To STORE
52.58%
When you buy 1 container of Glipizide 5mg for $32.72 at DoctorSolve compared to the max price for 90 of $69.00.
DoctorSolve Pharmacy is certified by
1 container (90): Glipizide 5mg
$32.72
Regular Shipping:
$9.95
Coupon Discount
$10.6675
Total:
$32.0025
Go To Store

Glipizide Prices from MapleLeafMeds

Glipizide Xl 5mg

90
Generic

$32.72

viewdetail

$ 0.36

Go To STORE
52.58%
When you buy 1 container of Glipizide Xl 5mg for $32.72 at MapleLeafMeds compared to the max price for 90 of $69.00.
MapleLeafMeds Pharmacy is certified by
1 container (90): Glipizide Xl 5mg
$32.72
Regular Shipping:
$9.95
Total:
$42.67
Go To Store

Glipizide Prices from PrescriptionPoint

Glipizide Xl 5mg

90
Generic

$32.72

viewdetail

$ 0.36

Go To STORE
52.58%
When you buy 1 container of Glipizide Xl 5mg for $32.72 at PrescriptionPoint compared to the max price for 90 of $69.00.
PrescriptionPoint Pharmacy is certified by
1 container (90): Glipizide Xl 5mg
$32.72
Regular Shipping:
$9.95
Total:
$42.67
Go To Store

Glipizide Prices from MapleLeafMeds

Glipizide 5mg

90
Generic

$32.72

viewdetail

$ 0.36

Go To STORE
52.58%
When you buy 1 container of Glipizide 5mg for $32.72 at MapleLeafMeds compared to the max price for 90 of $69.00.
MapleLeafMeds Pharmacy is certified by
1 container (90): Glipizide 5mg
$32.72
Regular Shipping:
$9.95
Total:
$42.67
Go To Store

Glipizide Prices from Canada Drug Center

Glipizide 2.5mg

100
Generic

$38.00

viewdetail

$ 0.38

Go To STORE
44.12%
When you buy 1 container of Glipizide 2.5mg for $38.00 at Canada Drug Center compared to the max price for 100 of $68.00.
Canada Drug Center Pharmacy is certified by
1 container (100): Glipizide 2.5mg
$38.00
Regular Shipping:
$9.99
Coupon Discount
$4.799
Total:
$43.191
Go To Store

Glipizide Prices from Canadian Pharmacy Meds

Glipizide 2.5mg

100
Generic

$39.00

viewdetail

$ 0.39

Go To STORE
42.65%
When you buy 1 container of Glipizide 2.5mg for $39.00 at Canadian Pharmacy Meds compared to the max price for 100 of $68.00.
Canadian Pharmacy Meds Pharmacy is certified by
1 container (100): Glipizide 2.5mg
$39.00
Regular Shipping:
$10.00
Coupon Discount
$4.9
Total:
$44.1
Go To Store

Glipizide Prices from Canada Drug Center

Glipizide ER 5mg

100
Generic

$39.00

viewdetail

$ 0.39

Go To STORE
42.65%
When you buy 1 container of Glipizide ER 5mg for $39.00 at Canada Drug Center compared to the max price for 100 of $68.00.
Canada Drug Center Pharmacy is certified by
1 container (100): Glipizide ER 5mg
$39.00
Regular Shipping:
$9.99
Coupon Discount
$4.899
Total:
$44.091
Go To Store

Glipizide Prices from Canada Drug Pharmacy

Glipizide 2.5mg

100
Generic

$40.00

viewdetail

$ 0.40

Go To STORE
41.18%
When you buy 1 container of Glipizide 2.5mg for $40.00 at Canada Drug Pharmacy compared to the max price for 100 of $68.00.
Canada Drug Pharmacy Pharmacy is certified by
1 container (100): Glipizide 2.5mg
$40.00
Regular Shipping:
$9.99
Coupon Discount
$4.999
Total:
$44.991
Go To Store

Glipizide Prices from Canadian Pharmacy Meds

Glipizide ER 5mg

100
Generic

$40.00

viewdetail

$ 0.40

Go To STORE
41.18%
When you buy 1 container of Glipizide ER 5mg for $40.00 at Canadian Pharmacy Meds compared to the max price for 100 of $68.00.
Canadian Pharmacy Meds Pharmacy is certified by
1 container (100): Glipizide ER 5mg
$40.00
Regular Shipping:
$10.00
Coupon Discount
$5
Total:
$45
Go To Store

Glipizide Prices from Canada Drug Pharmacy

Glipizide Er 5mg

100
Generic

$41.00

viewdetail

$ 0.41

Go To STORE
39.71%
When you buy 1 container of Glipizide Er 5mg for $41.00 at Canada Drug Pharmacy compared to the max price for 100 of $68.00.
Canada Drug Pharmacy Pharmacy is certified by
1 container (100): Glipizide Er 5mg
$41.00
Regular Shipping:
$9.99
Coupon Discount
$5.099
Total:
$45.891
Go To Store

Glipizide Prices from MapleLeafMeds

Glipizide 2.5mg

180
Generic

$74.00

viewdetail

$ 0.41

Go To STORE
41.73%
When you buy 1 container of Glipizide 2.5mg for $74.00 at MapleLeafMeds compared to the max price for 180 of $127.00.
MapleLeafMeds Pharmacy is certified by
1 container (180): Glipizide 2.5mg
$74.00
Regular Shipping:
$9.95
Total:
$83.95
Go To Store

Glipizide Prices from Quality Prescription Drugs

Glipizide 2.5mg

180
Generic

$84.00

viewdetail

$ 0.47

Go To STORE
33.86%
When you buy 1 container of Glipizide 2.5mg for $84.00 at Quality Prescription Drugs compared to the max price for 180 of $127.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (180): Glipizide 2.5mg
$84.00
Regular Shipping:
$9.00
Total:
$93
Go To Store

Glipizide Prices from Online Pharmacies Canada

Glipizide 2.5mg

180
Generic

$84.42

viewdetail

$ 0.47

Go To STORE
33.53%
When you buy 1 container of Glipizide 2.5mg for $84.42 at Online Pharmacies Canada compared to the max price for 180 of $127.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (180): Glipizide 2.5mg
$84.42
Regular Shipping:
$9.95
Total:
$94.37
Go To Store

Glipizide Prices from Pharma Passport

Glipizide 2.5mg

180
Generic

$84.84

viewdetail

$ 0.47

Go To STORE
33.20%
When you buy 1 container of Glipizide 2.5mg for $84.84 at Pharma Passport compared to the max price for 180 of $127.00.
1 container (180): Glipizide 2.5mg
$84.84
Regular Shipping:
$9.95
Total:
$94.79
Go To Store

Glipizide Prices from MapleLeafMeds

Glipizide Xl 2.5mg

90
Generic

$43.00

viewdetail

$ 0.48

Go To STORE
37.68%
When you buy 1 container of Glipizide Xl 2.5mg for $43.00 at MapleLeafMeds compared to the max price for 90 of $69.00.
MapleLeafMeds Pharmacy is certified by
1 container (90): Glipizide Xl 2.5mg
$43.00
Regular Shipping:
$9.95
Total:
$52.95
Go To Store

Glipizide Prices from MapleLeafMeds

Glipizide 2.5mg

90
Generic

$43.00

viewdetail

$ 0.48

Go To STORE
37.68%
When you buy 1 container of Glipizide 2.5mg for $43.00 at MapleLeafMeds compared to the max price for 90 of $69.00.
MapleLeafMeds Pharmacy is certified by
1 container (90): Glipizide 2.5mg
$43.00
Regular Shipping:
$9.95
Total:
$52.95
Go To Store

Glipizide Prices from Quality Prescription Drugs

Glipizide Xl 5mg

90
Generic

$46.00

viewdetail

$ 0.51

Go To STORE
33.33%
When you buy 1 container of Glipizide Xl 5mg for $46.00 at Quality Prescription Drugs compared to the max price for 90 of $69.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (90): Glipizide Xl 5mg
$46.00
Regular Shipping:
$9.00
Total:
$55
Go To Store

Glipizide Prices from PrescriptionPoint

Glipizide 2.5mg

180
Generic

$92.00

viewdetail

$ 0.51

Go To STORE
27.56%
When you buy 1 container of Glipizide 2.5mg for $92.00 at PrescriptionPoint compared to the max price for 180 of $127.00.
PrescriptionPoint Pharmacy is certified by
1 container (180): Glipizide 2.5mg
$92.00
Regular Shipping:
$9.95
Total:
$101.95
Go To Store

Glipizide Prices from DoctorSolve

Glipizide 2.5mg

180
Generic

$92.00

viewdetail

$ 0.51

Go To STORE
27.56%
When you buy 1 container of Glipizide 2.5mg for $92.00 at DoctorSolve compared to the max price for 180 of $127.00.
DoctorSolve Pharmacy is certified by
1 container (180): Glipizide 2.5mg
$92.00
Regular Shipping:
$9.95
Coupon Discount
$25.4875
Total:
$76.4625
Go To Store

Glipizide Prices from Quality Prescription Drugs

Glipizide 5mg

90
Generic

$46.00

viewdetail

$ 0.51

Go To STORE
33.33%
When you buy 1 container of Glipizide 5mg for $46.00 at Quality Prescription Drugs compared to the max price for 90 of $69.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (90): Glipizide 5mg
$46.00
Regular Shipping:
$9.00
Total:
$55
Go To Store

Glipizide Prices from Online Pharmacies Canada

Glipizide 5mg

90
Generic

$46.23

viewdetail

$ 0.51

Go To STORE
33.00%
When you buy 1 container of Glipizide 5mg for $46.23 at Online Pharmacies Canada compared to the max price for 90 of $69.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (90): Glipizide 5mg
$46.23
Regular Shipping:
$9.95
Total:
$56.18
Go To Store

Glipizide Prices from Online Pharmacies Canada

Glipizide Xl 5mg

90
Generic

$46.23

viewdetail

$ 0.51

Go To STORE
33.00%
When you buy 1 container of Glipizide Xl 5mg for $46.23 at Online Pharmacies Canada compared to the max price for 90 of $69.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (90): Glipizide Xl 5mg
$46.23
Regular Shipping:
$9.95
Total:
$56.18
Go To Store

Glipizide Prices from Pharma Passport

Glipizide Xl 5mg

90
Generic

$46.46

viewdetail

$ 0.52

Go To STORE
32.67%
When you buy 1 container of Glipizide Xl 5mg for $46.46 at Pharma Passport compared to the max price for 90 of $69.00.
1 container (90): Glipizide Xl 5mg
$46.46
Regular Shipping:
$9.95
Total:
$56.41
Go To Store

Glipizide Prices from Pharma Passport

Glipizide 5mg

90
Generic

$46.46

viewdetail

$ 0.52

Go To STORE
32.67%
When you buy 1 container of Glipizide 5mg for $46.46 at Pharma Passport compared to the max price for 90 of $69.00.
1 container (90): Glipizide 5mg
$46.46
Regular Shipping:
$9.95
Total:
$56.41
Go To Store

Glipizide Prices from Quality Prescription Drugs

Glipizide 2.5/500mg

180
Generic

$95.00

viewdetail

$ 0.53

Go To STORE
25.20%
When you buy 1 container of Glipizide 2.5/500mg for $95.00 at Quality Prescription Drugs compared to the max price for 180 of $127.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (180): Glipizide 2.5/500mg
$95.00
Regular Shipping:
$9.00
Total:
$104
Go To Store

Glipizide Prices from Online Pharmacies Canada

Glipizide 2.5/500mg

180
Generic

$95.47

viewdetail

$ 0.53

Go To STORE
24.83%
When you buy 1 container of Glipizide 2.5/500mg for $95.47 at Online Pharmacies Canada compared to the max price for 180 of $127.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (180): Glipizide 2.5/500mg
$95.47
Regular Shipping:
$9.95
Total:
$105.42
Go To Store

Glipizide Prices from Pharma Passport

Glipizide 2.5/500mg

180
Generic

$95.95

viewdetail

$ 0.53

Go To STORE
24.45%
When you buy 1 container of Glipizide 2.5/500mg for $95.95 at Pharma Passport compared to the max price for 180 of $127.00.
1 container (180): Glipizide 2.5/500mg
$95.95
Regular Shipping:
$9.95
Total:
$105.9
Go To Store

Glipizide Prices from Quality Prescription Drugs

Glipizide Xl 2.5mg

90
Generic

$48.00

viewdetail

$ 0.53

Go To STORE
30.43%
When you buy 1 container of Glipizide Xl 2.5mg for $48.00 at Quality Prescription Drugs compared to the max price for 90 of $69.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (90): Glipizide Xl 2.5mg
$48.00
Regular Shipping:
$9.00
Total:
$57
Go To Store

Glipizide Prices from Quality Prescription Drugs

Glipizide 2.5mg

90
Generic

$48.00

viewdetail

$ 0.53

Go To STORE
30.43%
When you buy 1 container of Glipizide 2.5mg for $48.00 at Quality Prescription Drugs compared to the max price for 90 of $69.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (90): Glipizide 2.5mg
$48.00
Regular Shipping:
$9.00
Total:
$57
Go To Store

Glipizide Prices from Online Pharmacies Canada

Glipizide 2.5mg

90
Generic

$48.24

viewdetail

$ 0.54

Go To STORE
30.09%
When you buy 1 container of Glipizide 2.5mg for $48.24 at Online Pharmacies Canada compared to the max price for 90 of $69.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (90): Glipizide 2.5mg
$48.24
Regular Shipping:
$9.95
Total:
$58.19
Go To Store

Glipizide Prices from Online Pharmacies Canada

Glipizide Xl 2.5mg

90
Generic

$48.24

viewdetail

$ 0.54

Go To STORE
30.09%
When you buy 1 container of Glipizide Xl 2.5mg for $48.24 at Online Pharmacies Canada compared to the max price for 90 of $69.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (90): Glipizide Xl 2.5mg
$48.24
Regular Shipping:
$9.95
Total:
$58.19
Go To Store

Glipizide Prices from Pharma Passport

Glipizide Xl 2.5mg

90
Generic

$48.48

viewdetail

$ 0.54

Go To STORE
29.74%
When you buy 1 container of Glipizide Xl 2.5mg for $48.48 at Pharma Passport compared to the max price for 90 of $69.00.
1 container (90): Glipizide Xl 2.5mg
$48.48
Regular Shipping:
$9.95
Total:
$58.43
Go To Store

Glipizide Prices from Pharma Passport

Glipizide 2.5mg

90
Generic

$48.48

viewdetail

$ 0.54

Go To STORE
29.74%
When you buy 1 container of Glipizide 2.5mg for $48.48 at Pharma Passport compared to the max price for 90 of $69.00.
1 container (90): Glipizide 2.5mg
$48.48
Regular Shipping:
$9.95
Total:
$58.43
Go To Store

Glipizide Prices from Quality Prescription Drugs

Glipizide/Metformin Hydrochloride 2.5/500mg

90
Generic

$49.00

viewdetail

$ 0.54

Go To STORE
28.99%
When you buy 1 container of Glipizide/Metformin Hydrochloride 2.5/500mg for $49.00 at Quality Prescription Drugs compared to the max price for 90 of $69.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (90): Glipizide/Metformin Hydrochloride 2.5/500mg
$49.00
Regular Shipping:
$9.00
Total:
$58
Go To Store

Glipizide Prices from Quality Prescription Drugs

Glipizide 2.5/500mg

90
Generic

$49.00

viewdetail

$ 0.54

Go To STORE
28.99%
When you buy 1 container of Glipizide 2.5/500mg for $49.00 at Quality Prescription Drugs compared to the max price for 90 of $69.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (90): Glipizide 2.5/500mg
$49.00
Regular Shipping:
$9.00
Total:
$58
Go To Store

Glipizide Prices from Online Pharmacies Canada

Glipizide 2.5/500mg

90
Generic

$49.24

viewdetail

$ 0.55

Go To STORE
28.64%
When you buy 1 container of Glipizide 2.5/500mg for $49.24 at Online Pharmacies Canada compared to the max price for 90 of $69.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (90): Glipizide 2.5/500mg
$49.24
Regular Shipping:
$9.95
Total:
$59.19
Go To Store

Glipizide Prices from Online Pharmacies Canada

Glipizide/Metformin Hydrochloride 2.5/500mg

90
Generic

$49.24

viewdetail

$ 0.55

Go To STORE
28.64%
When you buy 1 container of Glipizide/Metformin Hydrochloride 2.5/500mg for $49.24 at Online Pharmacies Canada compared to the max price for 90 of $69.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (90): Glipizide/Metformin Hydrochloride 2.5/500mg
$49.24
Regular Shipping:
$9.95
Total:
$59.19
Go To Store

Glipizide Prices from Pharma Passport

Glipizide/Metformin Hydrochloride 2.5/500mg

90
Generic

$49.49

viewdetail

$ 0.55

Go To STORE
28.28%
When you buy 1 container of Glipizide/Metformin Hydrochloride 2.5/500mg for $49.49 at Pharma Passport compared to the max price for 90 of $69.00.
1 container (90): Glipizide/Metformin Hydrochloride 2.5/500mg
$49.49
Regular Shipping:
$9.95
Total:
$59.44
Go To Store

Glipizide Prices from Pharma Passport

Glipizide 2.5/500mg

90
Generic

$49.49

viewdetail

$ 0.55

Go To STORE
28.28%
When you buy 1 container of Glipizide 2.5/500mg for $49.49 at Pharma Passport compared to the max price for 90 of $69.00.
1 container (90): Glipizide 2.5/500mg
$49.49
Regular Shipping:
$9.95
Total:
$59.44
Go To Store

Glipizide Prices from Online Canadian Pharmacy

Glipizide Xl 2.5mg

90
Generic

$51.48

viewdetail

$ 0.57

Go To STORE
25.39%
When you buy 1 container of Glipizide Xl 2.5mg for $51.48 at Online Canadian Pharmacy compared to the max price for 90 of $69.00.
1 container (90): Glipizide Xl 2.5mg
$51.48
Regular Shipping:
$0.00
Total:
$51.48
Go To Store

Glipizide Prices from PrescriptionPoint

Glipizide 2.5mg

90
Generic

$52.00

viewdetail

$ 0.58

Go To STORE
24.64%
When you buy 1 container of Glipizide 2.5mg for $52.00 at PrescriptionPoint compared to the max price for 90 of $69.00.
PrescriptionPoint Pharmacy is certified by
1 container (90): Glipizide 2.5mg
$52.00
Regular Shipping:
$9.95
Total:
$61.95
Go To Store

Glipizide Prices from DoctorSolve

Glipizide Xl 2.5mg

90
Generic

$52.00

viewdetail

$ 0.58

Go To STORE
24.64%
When you buy 1 container of Glipizide Xl 2.5mg for $52.00 at DoctorSolve compared to the max price for 90 of $69.00.
DoctorSolve Pharmacy is certified by
1 container (90): Glipizide Xl 2.5mg
$52.00
Regular Shipping:
$9.95
Coupon Discount
$15.4875
Total:
$46.4625
Go To Store

Glipizide Prices from DoctorSolve

Glipizide 2.5mg

90
Generic

$52.00

viewdetail

$ 0.58

Go To STORE
24.64%
When you buy 1 container of Glipizide 2.5mg for $52.00 at DoctorSolve compared to the max price for 90 of $69.00.
DoctorSolve Pharmacy is certified by
1 container (90): Glipizide 2.5mg
$52.00
Regular Shipping:
$9.95
Coupon Discount
$15.4875
Total:
$46.4625
Go To Store

Glipizide Prices from PrescriptionPoint

Glipizide Xl 2.5mg

90
Generic

$52.00

viewdetail

$ 0.58

Go To STORE
24.64%
When you buy 1 container of Glipizide Xl 2.5mg for $52.00 at PrescriptionPoint compared to the max price for 90 of $69.00.
PrescriptionPoint Pharmacy is certified by
1 container (90): Glipizide Xl 2.5mg
$52.00
Regular Shipping:
$9.95
Total:
$61.95
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90
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Glipizide Information

Company Name
Cardinal Health

Glipizide () Description

Glipizide () Tablets USP are oral blood-glucose-lowering drugs of the sulfonylurea class.

The Chemical Abstracts name of Glipizide () is 1-cyclohexyl-3-[[p-[2-(5-methylpyrazine- carboxamido)ethyl]phenyl]sulfonyl]urea and has the following structural formula:

CHNOS M.W. 445.55

Glipizide () is a whitish, odorless powder with a pKa of 5.9. It is insoluble in water and alcohols, but soluble in 0.1 NaOH; it is freely soluble in dimethylformamide. Glipizide () tablets for oral use are available in 5 and 10 mg strengths.

Each tablet contains the following inactive ingredients: lactose monohydrate; microcrystalline cellulose; pregelatinized starch; silicon dioxide; stearic acid.

Glipizide () Clinical Pharmacology

The primary mode of action of Glipizide () in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet tissue and is thus dependent on functioning beta cells in the pancreatic islets. In humans, Glipizide () appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which Glipizide () lowers blood glucose during long-term administration has not been clearly established. In man, stimulation of insulin secretion by Glipizide () in response to a meal is undoubtedly of major importance. Fasting insulin levels are not elevated even on long-term Glipizide () administration, but the postprandial insulin response continues to be enhanced after at least 6 months of treatment. The insulinotropic response to a meal occurs within 30 minutes after an oral dose of Glipizide () in diabetic patients, but elevated insulin levels do not persist beyond the time of the meal challenge. Extrapancreatic effects may play a part in the mechanism of action of oral sulfonylurea hypoglycemic drugs.

Blood sugar control persists in some patients for up to 24 hours after a single dose of Glipizide () , even though plasma levels have declined to a small fraction of peak levels by that time (see below).

Some patients fail to respond initially, or gradually lose their responsiveness to sulfonylurea drugs, including Glipizide () . Alternatively, Glipizide () may be effective in some patients who have not responded or have ceased to respond to other sulfonylureas.

It has been shown that Glipizide () therapy was effective in controlling blood sugar without deleterious changes in the plasma lipoprotein profiles of patients treated for NIDDM.

In a placebo-controlled, crossover study in normal volunteers, Glipizide () had no antidiuretic activity and, in fact, led to a slight increase in free water clearance.

Gastrointestinal absorption of Glipizide () in man is uniform, rapid, and essentially complete. Peak plasma concentrations occur 1 to 3 hours after a single oral dose. The half-life of elimination ranges from 2 to 4 hours in normal subjects, whether given intravenously or orally. The metabolic and excretory patterns are similar with the two routes of administration, indicating that first-pass metabolism is not significant. Glipizide () does not accumulate in plasma on repeated oral administration. Total absorption and disposition of an oral dose was unaffected by food in normal volunteers, but absorption was delayed by about 40 minutes. Thus, Glipizide () was more effective when administered about 30 minutes before, rather than with, a test meal in diabetic patients. Protein binding was studied in serum from volunteers who received either oral or intravenous Glipizide () and found to be 98 to 99% one hour after either route of administration. The apparent volume of distribution of Glipizide () after intravenous administration was 11 liters, indicative of localization within the extracellular fluid compartment. In mice, no Glipizide () or metabolites were detectable autoradiographically in the brain or spinal cord of males or females, nor in the fetuses of pregnant females. In another study, however, very small amounts of radioactivity were detected in the fetuses of rats given labelled drug.

The metabolism of Glipizide () is extensive and occurs mainly in the liver. The primary metabolites are inactive hydroxylation products and polar conjugates and are excreted mainly in the urine. Less than 10% unchanged Glipizide () is found in the urine.

Glipizide () Indications And Usage

Glipizide () Tablets USP are indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Glipizide () Contraindications

Glipizide () tablets are contraindicated in patients with:

Glipizide () Precautions

Patients should be informed of the potential risks and advantages of Glipizide () and of alternative modes of therapy. They should also be informed about the importance of adhering to dietary instructions, of a regular exercise program, and of regular testing of urine and/or blood glucose.

The risks of hypoglycemia, its symptoms and treatment, and conditions that predispose to its development should be explained to patients and responsible family members. Primary and secondary failure should also be explained.

The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including non-steroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta-adrenergic blocking agents. When such drugs are administered to a patient receiving Glipizide () , the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving Glipizide () , the patient should be observed closely for loss of control. binding studies with human serum proteins indicate that Glipizide () binds differently than tolbutamide and does not interact with salicylate or dicumarol. However, caution must be exercised in extrapolating these findings to the clinical situation and in the use of Glipizide () with these drugs.

Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Glipizide () , the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving Glipizide () , the patient should be observed closely for hypoglycemia.

A potential interaction between oral miconazole and oral hypoglycemic agents leading to severe hypoglycemia has been reported. Whether this interaction also occurs with the intravenous, topical, or vaginal preparations of miconazole is not known. The effect of concomitant administration of fluconazole and Glipizide () has been demonstrated in a placebo-controlled crossover study in normal volunteers. All subjects received Glipizide () alone and following treatment with 100 mg of fluconazole as a single daily oral dose for 7 days. The mean percentage increase in the Glipizide () AUC after fluconazole administration was 56.9% (range: 35 to 81).

Glipizide () Adverse Reactions

In U.S. and foreign controlled studies, the frequency of serious adverse reactions reported was very low. Of 702 patients, 11.8% reported adverse reactions and in only 1.5% was Glipizide () discontinued.

The following adverse events have been reported in postmarketing surveillance:

Glipizide () Overdosage

There is no well documented experience with Glipizide () overdosage. The acute oral toxicity was extremely low in all species tested (LD greater than 4 g/kg).

Overdosage of sulfonylureas, including Glipizide () , can produce hypoglycemia. Mild hypoglycemic symptoms without loss of consciousness or neurologic findings should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated (50%) glucose solution. This should be followed by a continuous infusion of a more dilute (10%) glucose solution at a rate that will maintain the blood glucose at a level above 100 mg/dL. Patients should be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may recur after apparent clinical recovery. Clearance of Glipizide () from plasma would be prolonged in persons with liver disease. Because of the extensive protein binding of Glipizide () , dialysis is unlikely to be of benefit.

Glipizide () Dosage And Administration

There is no fixed dosage regimen for the management of diabetes mellitus with Glipizide () or any other hypoglycemic agent. In addition to the usual monitoring of urinary glucose, the patient’s blood glucose must also be monitored periodically to determine the minimum effective dose for the patient; to detect primary failure, i.e., inadequate lowering of blood glucose at the maximum recommended dose of medication; and to detect secondary failure, i.e., loss of an adequate blood-glucose-lowering response after an initial period of effectiveness. Glycosylated hemoglobin levels may also be of value in monitoring the patient’s response to therapy.

Short-term administration of Glipizide () may be sufficient during periods of transient loss of control in patients usually controlled well on diet.

In general, Glipizide () should be given approximately 30 minutes before a meal to achieve the greatest reduction in postprandial hyperglycemia.

Glipizide () How Supplied

Glipizide () Tablets USP, 5 mg are available as white to off-white, round, flat-faced, beveled-edge tablets, bisected and debossed on one side with “9201” above bisect and debossed with “TEVA” on the other side, containing 5 mg of Glipizide () , packaged in bottles of 100 and 500 tablets and unit-dose boxes of 100 tablets.

Glipizide () Tablets USP, 10 mg are available as white to off-white, round, flat-faced, beveled-edge tablets, bisected and debossed on one side with “9200” above bisect and debossed with “TEVA” on the other side, containing 10 mg of Glipizide () , packaged in bottles of 100 and 500 tablets and unit-dose boxes of 100 tablets.

Dispense in a tight, light-resistant container as defined in the USP, with a child-resistant closure (as required).

Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].

KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.

Manufactured In Croatia By:

Zagreb, Croatia

Manufactured For:

Sellersville, PA 18960

Rev. E 2/2011

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Glipizide () Tablets USP
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