eDrugSearch uploadxml
eDrug Search

View drugs by alphabetical list:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

  • Home
  • Pharmacy Ratings
  • Blog
  • Community
  • Library
  • About Pharmacies
  • Tell a Friend:

You are here:Home»Prescription Drugs A to Z»Corgard

Corgard Price Comparison

Buy Corgard Online and Read Corgard Reviews

Use eDrugSearch to check Corgard price comparison results below and read verified Corgard reviews before you buy Corgard online. Simply click the "Buy Now" button or the "Pharmacy Logo" to buy Corgard online from one of our licensed Canadian pharmacies.

*To refine your Corgard price comparison search further click on the "All, Brand or Generic" tab so you can view all the Corgard prices located within our database.

Select Dosage

  • All dosages
  • 40mg Corgard
  • 80mg Corgard
  • 160mg Corgard
  • Compare Prices
  • Read Reviews
  • Q & A
  • Description
  • Coupons
  • All
  • Brand
  • Generic
Online Pharmacydesc
Drug Namedesc
Quantitydesc
Total Pricedesc
Price Per Pilldesc
Check Availability

Corgard Prices from MapleLeafMeds

Corgard 80mg

84
Brand

$48.00

viewdetail

$ 0.57

Go To STORE
31.42%
When you buy 1 container of Corgard 80mg for $48.00 at MapleLeafMeds compared to the max price for 84 of $69.99.
MapleLeafMeds Pharmacy is certified by
1 container (84): Corgard 80mg
$48.00
Regular Shipping:
$9.95
Total:
$57.95
Go To Store

Corgard Prices from Quality Prescription Drugs

Corgard 80mg

84
Brand

$55.00

viewdetail

$ 0.65

Go To STORE
21.42%
When you buy 1 container of Corgard 80mg for $55.00 at Quality Prescription Drugs compared to the max price for 84 of $69.99.
Quality Prescription Drugs Pharmacy is certified by
1 container (84): Corgard 80mg
$55.00
Regular Shipping:
$9.00
Total:
$64
Go To Store

Corgard Prices from Online Pharmacies Canada

Corgard 80mg

84
Brand

$55.27

viewdetail

$ 0.66

Go To STORE
21.03%
When you buy 1 container of Corgard 80mg for $55.27 at Online Pharmacies Canada compared to the max price for 84 of $69.99.
Online Pharmacies Canada Pharmacy is certified by
1 container (84): Corgard 80mg
$55.27
Regular Shipping:
$9.95
Total:
$65.22
Go To Store

Corgard Prices from Pharma Passport

Corgard 80mg

84
Brand

$55.55

viewdetail

$ 0.66

Go To STORE
20.63%
When you buy 1 container of Corgard 80mg for $55.55 at Pharma Passport compared to the max price for 84 of $69.99.
1 container (84): Corgard 80mg
$55.55
Regular Shipping:
$9.95
Total:
$65.5
Go To Store

Corgard Prices from PrescriptionPoint

Corgard 80mg

84
Brand

$69.00

viewdetail

$ 0.82

Go To STORE
1.41%
When you buy 1 container of Corgard 80mg for $69.00 at PrescriptionPoint compared to the max price for 84 of $69.99.
PrescriptionPoint Pharmacy is certified by
1 container (84): Corgard 80mg
$69.00
Regular Shipping:
$9.95
Total:
$78.95
Go To Store

Corgard Prices from DoctorSolve

Corgard 80mg

84
Brand

$69.00

viewdetail

$ 0.82

Go To STORE
1.41%
When you buy 1 container of Corgard 80mg for $69.00 at DoctorSolve compared to the max price for 84 of $69.99.
DoctorSolve Pharmacy is certified by
1 container (84): Corgard 80mg
$69.00
Regular Shipping:
$9.95
Coupon Discount
$19.7375
Total:
$59.2125
Go To Store

Corgard Prices from Online Canadian Pharmacy

Corgard 80mg

84
Brand

$69.69

viewdetail

$ 0.83

Go To STORE
0.43%
When you buy 1 container of Corgard 80mg for $69.69 at Online Canadian Pharmacy compared to the max price for 84 of $69.99.
1 container (84): Corgard 80mg
$69.69
Regular Shipping:
$0.00
Total:
$69.69
Go To Store

Corgard Prices from JanDrugs

Corgard 80mg

84 tablet
Brand

$69.99

viewdetail

$ 0.83

Go To STORE
0.00%
When you buy 1 container of Corgard 80mg for $69.99 at JanDrugs compared to the max price for 84 tablet of $69.99.
JanDrugs Pharmacy is certified by
1 container (84 tablet): Corgard 80mg
$69.99
Regular Shipping:
$0.00
Coupon Discount
$6.999
Total:
$62.991
Go To Store

Corgard Prices from Canada Drugs

Corgard 80mg

84 tablet
Brand

$69.99

viewdetail

$ 0.83

Go To STORE
0.00%
When you buy 1 container of Corgard 80mg for $69.99 at Canada Drugs compared to the max price for 84 tablet of $69.99.
Canada Drugs Pharmacy is certified by
1 container (84 tablet): Corgard 80mg
$69.99
Regular Shipping:
$0.00
Coupon Discount
$17.4975
Total:
$52.4925
Go To Store

Corgard Prices from JanDrugs

Corgard 80mg

28 tablet
Brand

$32.66

viewdetail

$ 1.17

Go To STORE
0.00%
When you buy 1 container of Corgard 80mg for $32.66 at JanDrugs compared to the max price for 28 tablet of $32.66.
JanDrugs Pharmacy is certified by
1 container (28 tablet): Corgard 80mg
$32.66
Regular Shipping:
$0.00
Coupon Discount
$3.266
Total:
$29.394
Go To Store

Corgard Prices from Canada Drugs

Corgard 80mg

28 tablet
Brand

$32.66

viewdetail

$ 1.17

Go To STORE
0.00%
When you buy 1 container of Corgard 80mg for $32.66 at Canada Drugs compared to the max price for 28 tablet of $32.66.
Canada Drugs Pharmacy is certified by
1 container (28 tablet): Corgard 80mg
$32.66
Regular Shipping:
$0.00
Coupon Discount
$8.165
Total:
$24.495
Go To Store

Corgard Information

Company Name
King Pharmaceuticals, Inc.

Corgard (Nadolol)

Corgard (Nadolol) Description

Corgard (Nadolol) is a synthetic nonselective beta-adrenergic receptor blocking agent designated chemically as 1-(-butylamino)-3-[(5,6,7,8-tetrahydro--6,7-dihydroxy-1-naphthyl)oxy]-2-propanol. Structural formula:

Nadolol is a white crystalline powder. It is freely soluble in ethanol, soluble in hydrochloric acid, slightly soluble in water and in chloroform, and very slightly soluble in sodium hydroxide.

Corgard (Nadolol) is available for oral administration as 20 mg, 40 mg, and 80 mg tablets. Inactive ingredients: microcrystalline cellulose, colorant (FD&C Blue No. 2), corn starch, magnesium stearate, povidone (except 20 mg and 40 mg), and other ingredients.

Corgard (Nadolol) Clinical Pharmacology

Corgard (Nadolol) is a nonselective beta-adrenergic receptor blocking agent. Clinical pharmacology studies have demonstrated beta-blocking activity by showing (1) reduction in heart rate and cardiac output at rest and on exercise, (2) reduction of systolic and diastolic blood pressure at rest and on exercise, (3) inhibition of isoproterenol-induced tachycardia, and (4) reduction of reflex orthostatic tachycardia.

Corgard (Nadolol) specifically competes with beta-adrenergic receptor agonists for available beta receptor sites; it inhibits both the beta receptors located chiefly in cardiac muscle and the beta receptors located chiefly in the bronchial and vascular musculature, inhibiting the chronotropic, inotropic, and vasodilator responses to beta-adrenergic stimulation proportionately. Corgard (Nadolol) has no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, nadolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane- stabilizing action. Animal and human studies show that Corgard (Nadolol) slows the sinus rate and depresses AV conduction. In dogs, only minimal amounts of nadolol were detected in the brain relative to amounts in blood and other organs and tissues. Corgard (Nadolol) has low lipophilicity as determined by octanol/water partition coefficient, a characteristic of certain beta-blocking agents that has been correlated with the limited extent to which these agents cross the blood-brain barrier, their low concentration in the brain, and low incidence of CNS-related side effects.

In controlled clinical studies, Corgard (Nadolol) at doses of 40 to 320 mg/day has been shown to decrease both standing and supine blood pressure, the effect persisting for approximately 24 hours after dosing.

The mechanism of the antihypertensive effects of beta-adrenergic receptor blocking agents has not been established; however, factors that may be involved include (1) competitive antagonism of catecholamines at peripheral (non-CNS) adrenergic neuron sites (especially cardiac) leading to decreased cardiac output, (2) a central effect leading to reduced tonic-sympathetic nerve outflow to the periphery, and (3) suppression of renin secretion by blockade of the beta-adrenergic receptors responsible for renin release from the kidneys.

While cardiac output and arterial pressure are reduced by nadolol therapy, renal hemodynamics are stable, with preservation of renal blood flow and glomerular filtration rate.

By blocking catecholamine-induced increases in heart rate, velocity and extent of myocardial contraction, and blood pressure, Corgard (Nadolol) generally reduces the oxygen requirements of the heart at any given level of effort, making it useful for many patients in the long-term management of angina pectoris. On the other hand, nadolol can increase oxygen requirements by increasing left ventricular fiber length and end diastolic pressure, particularly in patients with heart failure.

Although beta-adrenergic receptor blockade is useful in treatment of angina and hypertension, there are also situations in which sympathetic stimulation is vital. For example, in patients with severely damaged hearts, adequate ventricular function may depend on sympathetic drive. Beta-adrenergic blockade may worsen AV block by preventing the necessary facilitating effects of sympathetic activity on conduction. Beta-adrenergic blockade results in passive bronchial constriction by interfering with endogenous adrenergic bronchodilator activity in patients subject to bronchospasm and may also interfere with exogenous bronchodilators in such patients.

Absorption of nadolol after oral dosing is variable, averaging about 30 percent. Peak serum concentrations of nadolol usually occur in three to four hours after oral administration and the presence of food in the gastrointestinal tract does not affect the rate or extent of nadolol absorption. Approximately 30 percent of the nadolol present in serum is reversibly bound to plasma protein.

Unlike many other beta-adrenergic blocking agents, nadolol is not metabolized by the liver and is excreted unchanged, principally by the kidneys.

The half-life of therapeutic doses of nadolol is about 20 to 24 hours, permitting once-daily dosage. Because nadolol is excreted predominantly in the urine, its half-life increases in renal failure (see and ). Steady-state serum concentrations of nadolol are attained in six to nine days with once-daily dosage in persons with normal renal function. Because of variable absorption and different individual responsiveness, the proper dosage must be determined by titration.

Exacerbation of angina and, in some cases, myocardial infarction and ventricular dysrhythmias have been reported after abrupt discontinuation of therapy with beta-adrenergic blocking agents in patients with coronary artery disease. Abrupt withdrawal of these agents in patients without coronary artery disease has resulted in transient symptoms, including tremulousness, sweating, palpitation, headache, and malaise. Several mechanisms have been proposed to explain these phenomena, among them increased sensitivity to catecholamines because of increased numbers of beta receptors.

Corgard (Nadolol) Contraindications

Nadolol is contraindicated in bronchial asthma, sinus bradycardia and greater than first degree conduction block, cardiogenic shock, and overt cardiac failure (see ).

Corgard (Nadolol) Warnings

Sympathetic stimulation may be a vital component supporting circulatory function in patients with congestive heart failure, and its inhibition by beta-blockade may precipitate more severe failure. Although beta-blockers should be avoided in overt congestive heart failure, if necessary, they can be used with caution in patients with a history of failure who are well-compensated, usually with digitalis and diuretics. Beta-adrenergic blocking agents do not abolish the inotropic action of digitalis on heart muscle.

IN PATIENTS WITHOUT A HISTORY OF HEART FAILURE, continued use of beta-blockers can, in some cases, lead to cardiac failure. Therefore, at the first sign or symptom of heart failure, the patient should be digitalized and/or treated with diuretics, and the response observed closely, or nadolol should be discontinued (gradually, if possible).

Corgard (Nadolol) Precautions

When administered concurrently, the following drugs may interact with beta-adrenergic receptor blocking agents:

Catecholamine-depleting drugs (e.g., reserpine)
Digitalis glycosides
Response to Treatment for Anaphylactic Reaction

Corgard (Nadolol) Adverse Reactions

Most adverse effects have been mild and transient and have rarely required withdrawal of therapy.

Each of the following has been reported in 1 to 5 of 1000 patients: rash; pruritus; headache; dry mouth, eyes, or skin; impotence or decreased libido; facial swelling; weight gain; slurred speech; cough; nasal stuffiness; sweating; tinnitus; blurred vision. Reversible alopecia has been reported infrequently.

The following adverse reactions have been reported in patients taking nadolol and/or other beta-adrenergic blocking agents, but no causal relationship to nadolol has been established.

Pemphigoid rash; hypertensive reaction in patients with pheochromocytoma; sleep disturbances; Peyronie's disease.

The oculomucocutaneous syndrome associated with the beta-blocker practolol has not been reported with nadolol.

Corgard (Nadolol) Overdosage

Nadolol can be removed from the general circulation by hemodialysis.

In addition to gastric lavage, the following measures should be employed, as appropriate. In determining the duration of corrective therapy, note must be taken of the long duration of the effect of nadolol.

Corgard (Nadolol) Dosage And Administration

DOSAGE MUST BE INDIVIDUALIZED. Corgard (Nadolol) MAY BE ADMINISTERED WITHOUT REGARD TO MEALS.

The usual initial dose is 40 mg Corgard (Nadolol) once daily. Dosage may be gradually increased in 40 to 80 mg increments at 3 to 7 day intervals until optimum clinical response is obtained or there is pronounced slowing of the heart rate. The usual maintenance dose is 40 or 80 mg administered once daily. Doses up to 160 or 240 mg administered once daily may be needed.

The usefulness and safety in angina pectoris of dosage exceeding 240 mg per day have not been established. If treatment is to be discontinued, reduce the dosage gradually over a period of one to two weeks (see ).

Corgard (Nadolol) How Supplied

Corgard (Nadolol) Tablets (Nadolol Tablets USP)

All tablets are scored (bisect bar) and easy to break. Tablet identification numbers: 20 mg, ; 40 mg, ; and 80 mg, .

Corgard (Nadolol) Storage

Store at room temperature; avoid excessive heat. Protect from light. Keep bottle tightly closed.

Prescribing Information as of February 2011.

Manufactured and Distributed by: King Pharmaceuticals, Inc., Bristol, TN 37620

Corgard (Nadolol) Labelgraphics

Corgard (Nadolol) Labelgraphics

Corgard (Nadolol) Labelgraphics

Featured In
footer logo
©2015,eDrugSearch,Inc. All Rights Reserved. Privacy Policy Terms of Use Contact UsSitemap
Sign In

Email Address
Password
 
Remember Me Forgot your password?
Create Account
Forgot Password

If you've forgotten your password, please enter your email address below. We'll send you an email with instructions for resetting your password.

Email Address
Create Account

Name
Email ID
Password
Human Verification
Please type the characters you see in the image.
 
I have read and agree to the terms of service
Sign In
Submit Your Blog

Sorry ! only healthcare users can submit blogs. Please Click here to login or sign up for Healthcare User.