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Biltricide Price Comparison

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Biltricide Prices from MapleLeafMeds

Biltricide 600mg

18
Brand

$147.00

viewdetail

$ 8.17

Go To STORE
30.00%
When you buy 1 container of Biltricide 600mg for $147.00 at MapleLeafMeds compared to the max price for 18 of $210.00.
MapleLeafMeds Pharmacy is certified by
1 container (18): Biltricide 600mg
$147.00
Regular Shipping:
$9.95
Total:
$156.95
Go To Store

Biltricide Prices from Quality Prescription Drugs

Biltricide 600mg

18
Brand

$147.00

viewdetail

$ 8.17

Go To STORE
30.00%
When you buy 1 container of Biltricide 600mg for $147.00 at Quality Prescription Drugs compared to the max price for 18 of $210.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (18): Biltricide 600mg
$147.00
Regular Shipping:
$9.00
Total:
$156
Go To Store

Biltricide Prices from Online Pharmacies Canada

Biltricide 600mg

18
Brand

$147.74

viewdetail

$ 8.21

Go To STORE
29.65%
When you buy 1 container of Biltricide 600mg for $147.74 at Online Pharmacies Canada compared to the max price for 18 of $210.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (18): Biltricide 600mg
$147.74
Regular Shipping:
$9.95
Total:
$157.69
Go To Store

Biltricide Prices from Pharma Passport

Biltricide 600mg

18
Brand

$148.47

viewdetail

$ 8.25

Go To STORE
29.30%
When you buy 1 container of Biltricide 600mg for $148.47 at Pharma Passport compared to the max price for 18 of $210.00.
1 container (18): Biltricide 600mg
$148.47
Regular Shipping:
$9.95
Total:
$158.42
Go To Store

Biltricide Prices from MapleLeafMeds

Biltricide 600mg

12
Brand

$103.00

viewdetail

$ 8.58

Go To STORE
17.09%
When you buy 1 container of Biltricide 600mg for $103.00 at MapleLeafMeds compared to the max price for 12 of $124.23.
MapleLeafMeds Pharmacy is certified by
1 container (12): Biltricide 600mg
$103.00
Regular Shipping:
$9.95
Total:
$112.95
Go To Store

Biltricide Prices from Quality Prescription Drugs

Biltricide 600mg

12
Brand

$103.00

viewdetail

$ 8.58

Go To STORE
17.09%
When you buy 1 container of Biltricide 600mg for $103.00 at Quality Prescription Drugs compared to the max price for 12 of $124.23.
Quality Prescription Drugs Pharmacy is certified by
1 container (12): Biltricide 600mg
$103.00
Regular Shipping:
$9.00
Total:
$112
Go To Store

Biltricide Prices from Online Pharmacies Canada

Biltricide 600mg

12
Brand

$103.52

viewdetail

$ 8.63

Go To STORE
16.67%
When you buy 1 container of Biltricide 600mg for $103.52 at Online Pharmacies Canada compared to the max price for 12 of $124.23.
Online Pharmacies Canada Pharmacy is certified by
1 container (12): Biltricide 600mg
$103.52
Regular Shipping:
$9.95
Total:
$113.47
Go To Store

Biltricide Prices from Pharma Passport

Biltricide 600mg

12
Brand

$104.03

viewdetail

$ 8.67

Go To STORE
16.26%
When you buy 1 container of Biltricide 600mg for $104.03 at Pharma Passport compared to the max price for 12 of $124.23.
1 container (12): Biltricide 600mg
$104.03
Regular Shipping:
$9.95
Total:
$113.98
Go To Store

Biltricide Prices from PrescriptionPoint

Biltricide 600mg

18
Brand

$177.00

viewdetail

$ 9.83

Go To STORE
15.71%
When you buy 1 container of Biltricide 600mg for $177.00 at PrescriptionPoint compared to the max price for 18 of $210.00.
PrescriptionPoint Pharmacy is certified by
1 container (18): Biltricide 600mg
$177.00
Regular Shipping:
$9.95
Total:
$186.95
Go To Store

Biltricide Prices from DoctorSolve

Biltricide 600mg

18
Brand

$177.00

viewdetail

$ 9.83

Go To STORE
15.71%
When you buy 1 container of Biltricide 600mg for $177.00 at DoctorSolve compared to the max price for 18 of $210.00.
DoctorSolve Pharmacy is certified by
1 container (18): Biltricide 600mg
$177.00
Regular Shipping:
$9.95
Coupon Discount
$46.7375
Total:
$140.2125
Go To Store

Biltricide Prices from MapleLeafMeds

Biltricide 600mg

6
Brand

$59.00

viewdetail

$ 9.83

Go To STORE
21.33%
When you buy 1 container of Biltricide 600mg for $59.00 at MapleLeafMeds compared to the max price for 6 of $75.00.
MapleLeafMeds Pharmacy is certified by
1 container (6): Biltricide 600mg
$59.00
Regular Shipping:
$9.95
Total:
$68.95
Go To Store

Biltricide Prices from Quality Prescription Drugs

Biltricide 600mg

6
Brand

$59.00

viewdetail

$ 9.83

Go To STORE
21.33%
When you buy 1 container of Biltricide 600mg for $59.00 at Quality Prescription Drugs compared to the max price for 6 of $75.00.
Quality Prescription Drugs Pharmacy is certified by
1 container (6): Biltricide 600mg
$59.00
Regular Shipping:
$9.00
Total:
$68
Go To Store

Biltricide Prices from Online Pharmacies Canada

Biltricide 600mg

6
Brand

$59.30

viewdetail

$ 9.88

Go To STORE
20.93%
When you buy 1 container of Biltricide 600mg for $59.30 at Online Pharmacies Canada compared to the max price for 6 of $75.00.
Online Pharmacies Canada Pharmacy is certified by
1 container (6): Biltricide 600mg
$59.30
Regular Shipping:
$9.95
Total:
$69.25
Go To Store

Biltricide Prices from Pharma Passport

Biltricide 600mg

6
Brand

$59.59

viewdetail

$ 9.93

Go To STORE
20.55%
When you buy 1 container of Biltricide 600mg for $59.59 at Pharma Passport compared to the max price for 6 of $75.00.
1 container (6): Biltricide 600mg
$59.59
Regular Shipping:
$9.95
Total:
$69.54
Go To Store

Biltricide Prices from Online Canadian Pharmacy

Biltricide 600mg

18
Brand

$178.77

viewdetail

$ 9.93

Go To STORE
14.87%
When you buy 1 container of Biltricide 600mg for $178.77 at Online Canadian Pharmacy compared to the max price for 18 of $210.00.
1 container (18): Biltricide 600mg
$178.77
Regular Shipping:
$0.00
Total:
$178.77
Go To Store

Biltricide Prices from PrescriptionPoint

Biltricide 600mg

12
Brand

$123.00

viewdetail

$ 10.25

Go To STORE
0.99%
When you buy 1 container of Biltricide 600mg for $123.00 at PrescriptionPoint compared to the max price for 12 of $124.23.
PrescriptionPoint Pharmacy is certified by
1 container (12): Biltricide 600mg
$123.00
Regular Shipping:
$9.95
Total:
$132.95
Go To Store

Biltricide Prices from DoctorSolve

Biltricide 600mg

12
Brand

$123.00

viewdetail

$ 10.25

Go To STORE
0.99%
When you buy 1 container of Biltricide 600mg for $123.00 at DoctorSolve compared to the max price for 12 of $124.23.
DoctorSolve Pharmacy is certified by
1 container (12): Biltricide 600mg
$123.00
Regular Shipping:
$9.95
Coupon Discount
$33.2375
Total:
$99.7125
Go To Store

Biltricide Prices from Online Canadian Pharmacy

Biltricide 600mg

12
Brand

$124.23

viewdetail

$ 10.35

Go To STORE
0.00%
When you buy 1 container of Biltricide 600mg for $124.23 at Online Canadian Pharmacy compared to the max price for 12 of $124.23.
1 container (12): Biltricide 600mg
$124.23
Regular Shipping:
$0.00
Total:
$124.23
Go To Store

Biltricide Prices from CanadianPharmacyKing

Biltricide 600 mg

6
Brand

$63.00

viewdetail

$ 10.50

Go To STORE
16.00%
When you buy 1 container of Biltricide 600 mg for $63.00 at CanadianPharmacyKing compared to the max price for 6 of $75.00.
CanadianPharmacyKing Pharmacy is certified by
1 container (6): Biltricide 600 mg
$63.00
Regular Shipping:
$10.00
Total:
$73
Go To Store

Biltricide Prices from PrescriptionPoint

Biltricide 600mg

6
Brand

$69.00

viewdetail

$ 11.50

Go To STORE
8.00%
When you buy 1 container of Biltricide 600mg for $69.00 at PrescriptionPoint compared to the max price for 6 of $75.00.
PrescriptionPoint Pharmacy is certified by
1 container (6): Biltricide 600mg
$69.00
Regular Shipping:
$9.95
Total:
$78.95
Go To Store

Biltricide Prices from DoctorSolve

Biltricide 600mg

6
Brand

$69.00

viewdetail

$ 11.50

Go To STORE
8.00%
When you buy 1 container of Biltricide 600mg for $69.00 at DoctorSolve compared to the max price for 6 of $75.00.
DoctorSolve Pharmacy is certified by
1 container (6): Biltricide 600mg
$69.00
Regular Shipping:
$9.95
Coupon Discount
$19.7375
Total:
$59.2125
Go To Store

Biltricide Prices from Online Canadian Pharmacy

Biltricide 600mg

6
Brand

$69.69

viewdetail

$ 11.62

Go To STORE
7.08%
When you buy 1 container of Biltricide 600mg for $69.69 at Online Canadian Pharmacy compared to the max price for 6 of $75.00.
1 container (6): Biltricide 600mg
$69.69
Regular Shipping:
$0.00
Total:
$69.69
Go To Store

Biltricide Prices from JanDrugs

Biltricide 600mg

18 tablet
Brand

$210.00

viewdetail

$ 11.67

Go To STORE
0.00%
When you buy 1 container of Biltricide 600mg for $210.00 at JanDrugs compared to the max price for 18 tablet of $210.00.
JanDrugs Pharmacy is certified by
1 container (18 tablet): Biltricide 600mg
$210.00
Regular Shipping:
$0.00
Coupon Discount
$21
Total:
$189
Go To Store

Biltricide Prices from Canada Drugs

Biltricide 600mg

18 tablet
Brand

$210.00

viewdetail

$ 11.67

Go To STORE
0.00%
When you buy 1 container of Biltricide 600mg for $210.00 at Canada Drugs compared to the max price for 18 tablet of $210.00.
Canada Drugs Pharmacy is certified by
1 container (18 tablet): Biltricide 600mg
$210.00
Regular Shipping:
$0.00
Coupon Discount
$52.5
Total:
$157.5
Go To Store

Biltricide Prices from JanDrugs

Biltricide 600mg

6 tablet
Brand

$75.00

viewdetail

$ 12.50

Go To STORE
0.00%
When you buy 1 container of Biltricide 600mg for $75.00 at JanDrugs compared to the max price for 6 tablet of $75.00.
JanDrugs Pharmacy is certified by
1 container (6 tablet): Biltricide 600mg
$75.00
Regular Shipping:
$0.00
Coupon Discount
$7.5
Total:
$67.5
Go To Store

Biltricide Prices from Canada Drugs

Biltricide 600mg

6 tablet
Brand

$75.00

viewdetail

$ 12.50

Go To STORE
0.00%
When you buy 1 container of Biltricide 600mg for $75.00 at Canada Drugs compared to the max price for 6 tablet of $75.00.
Canada Drugs Pharmacy is certified by
1 container (6 tablet): Biltricide 600mg
$75.00
Regular Shipping:
$0.00
Coupon Discount
$18.75
Total:
$56.25
Go To Store

Biltricide Information

Product Code
50419-747
Company Name
Bayer HealthCare Pharmaceuticals Inc.
Dosage From
TABLET, FILM COATED
Strength
600 mg
Active Ingredient
PRAZIQUANTEL

Biltricide () Description

Biltricide () (praziquantel) is a trematodicide provided in tablet form for the oral treatment of schistosome infections and infections due to liver fluke.

Biltricide ()   (praziquantel) is 2-(cyclohexylcarbonyl)-1,2,3,6,7, 11b-hexahydro-4H-pyrazino [2, 1-a] isoquinolin-4-one with the molecular formula; CHNO. The structural formula is as follows:

Praziquantel is a white to nearly white crystalline powder of bitter taste. The compound is stable under normal conditions and melts at 136-140°C with decomposition. The active substance is hygroscopic. Praziquantel is easily soluble in chloroform and dimethylsulfoxide, soluble in ethanol and very slightly soluble in water.

Biltricide () tablets contain 600 mg of praziquantel. Inactive ingredients: corn starch, magnesium stearate, microcrystalline cellulose, povidone, sodium lauryl sulfate, polyethylene glycol, titanium dioxide and hypromellose.

Biltricide () Clinical Pharmacology

Praziquantel induces a rapid contraction of schistosomes by a specific effect on the permeability of the cell membrane. The drug further causes vacuolization and disintegration of the schistosome tegument.

After oral administration Biltricide () is rapidly absorbed (80%), subjected to a first pass effect, metabolized and eliminated by the kidneys. Maximal serum concentration is achieved 1-3 hours after dosing. The half-life of praziquantel in serum is 0.8-1.5 hours.

Biltricide () Indications And Usage

Biltricide () is indicated for the treatment of infections due to: all species of schistosoma (for example, and ), and infections due to the liver flukes, (approval of this indication was based on studies in which the two species were not differentiated).

Biltricide () Contraindications

Biltricide () is contraindicated in patients who previously have shown hypersensitivity to the drug or any of the excipients. Since parasite destruction within the eye may cause irreversible lesions, ocular cysticercosis must not be treated with this compound.

Concomitant administration with strong Cytochrome P450 (P450) inducers, such as rifampin, is contraindicated since therapeutically effective blood levels of praziquantel may not be achieved (see PRECAUTIONS/Drug Interactions). In patients receiving rifampin who need immediate treatment for schistosomiasis, alternative agents for schistosomiasis should be considered. However, if treatment with praziquantel is necessary, rifampin should be discontinued 4 weeks before administration of praziquantel. Treatment with rifampin can then be restarted one day after completion of praziquantel treatment (see PRECAUTIONS/).

Biltricide () Warnings

Therapeutically effective levels of Biltricide () may not be achieved when administered concomitantly with strong P450 inducers, such as rifampin (see ).

Biltricide () Precautions

Approximately 80% of a dose of praziquantel is excreted in the kidneys, almost exclusively (>99%) in the form of metabolites. Excretion might be delayed in patients with impaired renal function, but accumulation of unchanged drug would not be expected. Therefore, dose adjustment for renal impairment is not considered necessary. Nephrotoxic effects of praziquantel or its metabolites are not known.

Caution should be exercised in the administration of the usual recommended dose of praziquantel to hepatosplenic schistosomiasis patients with moderate to severe liver impairment (Child-Pugh class B and C). Reduced metabolism of praziquantel by the liver in these patients may lead to considerably higher and longer lasting plasma concentrations of unmetabolized praziquantel (See ).

Minimal increases in liver enzymes have been reported in some patients.

Patients suffering from cardiac irregularities should be monitored during treatment.

As Biltricide () can exacerbate central nervous system pathology due to schistosomiasis, as a general rule this drug should not be administered to individuals reporting a history of epilepsy and/or other signs of potential central nervous systems involvement such as subcutaneous nodules suggestive of cysticercosis.

When schistosomiasis or fluke infection is found to be associated with cerebral cysticercosis it is advised to hospitalize the patient for the duration of treatment.

Concomitant administration of rifampin, a strong P450 inducer, with praziquantel is contraindicated and must be avoided (see ). In a crossover study with a 2-week washout period, 10 healthy subjects ingested a single 40 mg/kg dose of praziquantel following pre-treatment with oral rifampin (600 mg daily for 5 days). Plasma praziquantel concentrations were undetectable in 7 out of 10 subjects. When a single 40 mg/kg dose of praziquantel was administered to these healthy subjects two weeks after discontinuation of rifampin, the mean praziquantel AUC and C were 23% and 35% lower, respectively, than when praziquantel was given alone. In patients receiving rifampin, for example, as part of a combination regimen for the treatment of tuberculosis, alternative agents for schistosomiasis should be considered. However, if treatment with praziquantel is necessary, treatment with rifampin should be discontinued 4 weeks before administration of praziquantel. Treatment with rifampin can then be restarted one day after completion of praziquantel treatment.

Concomitant administration of other drugs that increase the activity of drug metabolizing liver enzymes (P450 inducers), for example, antiepileptic drugs (phenytoin, phenobarbital and carbamazepine), and dexamethasone, may also reduce plasma levels of praziquantel. Concomitant administration of drugs that decrease the activity of drug metabolizing liver enzymes (P 450 inhibitors), for example, cimetidine, ketoconazole, itraconazole, erythromycin may increase plasma levels of praziquantel.

Chloroquine, when taken simultaneously, may lead to lower concentrations of praziquantel in blood. The mechanism of this drug-drug interaction is unclear.

Grapefruit juice was reported to produce a 1.6-fold increase in the Cand a 1.9-fold increase in the AUC of praziquantel. However, the effect of this exposure increase on the therapeutic effect and safety of praziquantel has not been systematically evaluated.

Clinical studies of praziquantel did not include a sufficient number of subjects ages 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older patients cannot be ruled out.

This drug is known to be substantially excreted by the kidney. Because elderly patients are more likely to have decreased renal function, the risk of toxic reactions to this drug may be greater in these patients.

Biltricide () Adverse Events

In general Biltricide ()   is very well tolerated. Side effects are usually mild and transient and do not require treatment. The following side effects were observed generally in order of severity: malaise, headache, dizziness, abdominal discomfort with or without nausea, rise in temperature and, rarely, urticaria. Such symptoms can, however, also result from the infection itself. Such side effects may be more frequent and/or serious in patients with a heavy worm burden.

Biltricide () Overdosage

In rats and mice the acute LD was about 2,500 mg/kg. No data are available in humans. In the event of overdose a fast-acting laxative should be given.

Biltricide () Dosage And Administration

The dosage recommended for the treatment of schistosomiasis is: 20 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. The recommended dose for clonorchiasis and opisthorchiasis is: 25 mg/kg bodyweight three times a day as a one day treatment, at intervals of not less than 4 hours and not more than 6 hours. The tablets should be washed down unchewed with water during meals. Keeping the tablets or segments thereof in the mouth can reveal a bitter taste which can promote gagging or vomiting.

Biltricide () How Supplied

Biltricide ()   is supplied as a 600 mg white to orange tinged, film-coated, oblong tablet with three scores. The tablet is coded with “BAYER” on one side and “LG” on the reverse side. When broken, each of the four segments contains 150 mg of active ingredient so that the dosage can be easily adjusted to the patient’s bodyweight.

Segments are broken off by pressing the score (notch) with thumbnails. If 1/4 of a tablet is required, this is best achieved by breaking the segment from the outer end.

Biltricide () is available in bottles of 6 tablets.

Manufactured for:

Bayer HealthCare Pharmaceuticals Inc.Wayne, NJ 07470Manufactured in Germany

04/11   

©2011 Bayer HealthCare Pharmaceuticals Inc.      Printed in USA

Biltricide ()

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