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News on Nefazodone hydrochloride (Serzone)

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Nefazodone hydrochloride (Serzone)

Last updated on: Jan 24, 2007

What Is Nefazodone?

Nefazodone is a medicine that is used to treat depression.

Who Should Not Take Nefazodone?

Never take nefazodone if you:

Have liver problems
Are allergic to the medicine Desyrel (trazodone)
Take the following medicines:
- Halcion (triazolam), a drug to treat trouble sleeping. Nefazodone can increase the amount of Halcion in your body, causing serious side effects.
- Orap (pimozide), a drug to treat Tourette?s syndrome, because it can result in serious heartbeat problems.
- Tegretol (carbamazepine), a drug to control seizures. Tegretol can reduce the amount of nefazodone in your body so that it does not help your depression.
Take another drug used to treat depression, called a Monoamine Oxidase Inhibitor (MAOI), or if you have stopped taking a MAOI in the last 14 days. Taking nefazodone close in time to a MAOI can result in serious, sometimes fatal, reactions, including:
- High body temperature
- Coma
- Seizures (convulsions)

MAOI drugs include Nardil (phenelzine sulfate), Parnate (tranylcypromine sulfate), Marplan (isocarboxazid), and other brands.

What Are The Risks?

Life-threatening liver failure. See Warning.
Suicidal thought or actions. See FDA Alert.
Low blood pressure (postural hypotension) and fainting. Low blood pressure can be serious for people with heart problems, strokes, dehydration, and who take medicines to control blood pressure.
Mania: You may become hyperactive, excitable or elated.
Seizures. You may have a seizure (convulsion), even if you are not taking nefazodone close in time with a MAOI.
An erection that won't go away (priapism). Get medical help right away for an erection that lasts for more than 4 hours.
Other side effects include sleepiness, dry mouth, nausea, dizziness, constipation, weakness, lightheadedness, vision problems, and confusion
Tell your healthcare professional about all your medical conditions especially if you have or have had heart problems, a heart attack, a stroke, or mania; if you are pregnant or plan to become pregnant; or if you are breast-feeding or plan to breast-feed your baby.

Are There Any Interactions With Medicines Or Foods?

Nefazodone can interact with Xanax (alprazolam), an anti-anxiety medicine. Your dose of Xanax should be decreased if used with nefazodone.
Nefazodone may interact with medicines other than the ones already mentioned in this information sheet, causing serious side effects. Tell your healthcare professional about all the medicines, vitamins, and herbal supplements you take, especially medicines for mental illness, depression, seizures, and immunosuppressants.
If you plan to drink alcohol, talk to your healthcare professional.

How Do I Take Nefazodone?

Nefazodone is taken by mouth, with or without food, twice a day.

This information is provided by the U.S. Food & Drug Administration.
For more information about this drug, click here.