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News on Kaletra (lopinavir; ritonavir)

Preventive HIV Therapy May Limit Later Response - MedPage Today

MD News (press release)Preventive HIV Therapy May Limit Later ResponseMedPage TodayIn concurrent parallel trials, they were treated with a combination of tenofovir and emtricitabine (Truvada) plus either nevirapine or lopinavir-ritonavir. ...Nevirapine May Not Always Be Best Choice for Peripartum Antiretroviral TreatmentMedscapeStudies Tout Alternative HIV Regimens for Women, BabiesBusinessWeekWHO Updates HIV Treatment Guidelines for Women and InfantsAIDSmeds.com HIV/AIDS Treatment NewsPediatric SuperSite�-MD News (press release)all 28 news articles��

Viread(R) for Hepatitis B Maintains Antiviral Suppression with No Development ... - MarketWatch (press release)

Viread(R) for Hepatitis B Maintains Antiviral Suppression with No Development ...MarketWatch (press release)Use atazanavir with Viread only with additional ritonavir; monitor for evidence of tenofovir toxicity. Coadministration of Viread with lopinavir/ritonavir ...and more��

Abbott earnings hit by charges but pharma sales soar - Pharma Times

Abbott earnings hit by charges but pharma sales soarPharma Times... therapy Lupron (leuprolide) fell 3.3% to $189 million, while revenues from the HIV drug Kaletra (lopinavir/ritonavir) plunged 7.2% to $328 million. ...and more��

Studies Indicate Kaletra-Based Therapy Is Better Than Viramune-Based Therapy ... - The AIDS Beacon

Studies Indicate Kaletra-Based Therapy Is Better Than Viramune-Based Therapy ...The AIDS BeaconThe WHO now recommends that Kaletra (ritonavir/lopinavir)-based treatment be used for women and children with previous exposure to single-dose Viramune ...

Kaletra (lopinavir; ritonavir)

Last updated on: Jan 24, 2007

Brand Name:	Arava
Active Ingredient:	lopinavir/ritonavir
Strength(s):	133.3/33.3mg Capsules, 80/20mg/ml Oral Solution and 200/50mg Tablets
Dosage Form(s):	Capsules, Oral Solution and Tablets
Company Name:	Abbott Pharmaceuticals
Availability:	Prescription only
*Date Approved by FDA:	September 15, 2000
*Approval by FDA does not mean that the drug is available for consumers at this time. This information is provided by the U.S. Food & Drug Administration. For more information about this drug, click here.

What is Kaletra used for?

Kaletra is always used in combination with other anti-HIV drugs to treat people with human immunodeficiency virus (HIV) infection. Kaletra is for adults and children 6 months and older.
Kaletra does not cure HIV infection or AIDS. The long-term effects of Kaletra are not known at this time. You may continue to develop infections and other complications associated with HIV disease.
Kaletra does not reduce the risk of transmitting HIV to others through sexual contact or blood contamination. Continue to practice safe sex, and do not use or share dirty needles.

Who should not take Kaletra?

Together with your doctor, you need to decide whether Kaletra is right for you.

Taking certain drugs with Kaletra could cause serious side effects that could cause death. Before you start Kaletra you must tell your doctor about ALL the drugs you are taking or are planning to take. These include other prescription and non-prescription medicines and herbal supplements such as St. John?s wort.
For more information about medicines you should not take with Kaletra, and medicines that require dosage adjustments click on the link below to Kaletra?s approved labeling and patient information.
Do not take Kaletra if you have had a serious allergic reaction to Kaletra or any of its ingredients, including ritonavir or lopinavir.

Special Warnings with Kaletra:

Kaletra may cause liver problems. Liver disease such as Hepatitis B and Hepatitis C may worsen when Kaletra is taken. In studies, it is unclear if Kaletra caused these liver problems because some patients had other illnesses or were taking other medications.
Some people taking Kaletra develop serious problems with their pancreas (pancreatitis), which may cause death. You have a higher chance of having pancreatitis if you have had it before. Tell your doctor if have nausea, vomiting, or abdominal pain. These may be signs of pancreatitis.
Changes in body fat happen in some people taking anti-HIV medicines. These changes may include increased amount of fat in the upper back and neck ("buffalo hump"), breast and abdomen (stomach area). Loss of fat from the face, legs, and arms may also happen. The cause and long-term health effects of these conditions are not known at this time.
Some patients with hemophilia have increased bleeding with this type of drug.
If you are taking oral contraceptives ("the pill") to prevent pregnancy, you should use an additional or different type of contraception since Kaletra may reduce the effectiveness of oral contraceptives.

What should I tell my doctor or healthcare provider?

Tell your doctor or healthcare provider if you:

are trying to become pregnant, are already pregnant, or are breast-feeding
have liver problems
have diabetes or an increase in thirst or frequent urination
have hemophilia

What are some possible side effects of Kaletra? (This is NOT a complete list of side effects reported with Kaletra. Your healthcare provider can discuss with you a more complete list of side effects.)

The most commonly reported side effects that are thought to be drug related are: