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News on Gleevec (imatinib mesylate)

FDA Approves Sprycel As First-Line Leukemia Treatment - Wall Street Journal

FDA Approves Sprycel As First-Line Leukemia TreatmentWall Street Journal... so-called Philadelphia chromosome positive chronic phase chronic myeloid leukemia after other treatments such as Novartis AG's (NVS) Gleevec had failed. ...Sprycel Approval Expanded to Include Rare LeukemiaBusinessWeekFDA approves new use for leukemia drugmsnbc.comFDA Approves Additional Medical Indication for SprycelPR Newswire (press release)MarketWatch (press release)�-Internal Medicine News Digital Network�-TopNews United Statesall 90 news articles��

Some With Once-Deadly Leukemia Can Take a Break From Gleevec - BusinessWeek

Some With Once-Deadly Leukemia Can Take a Break From GleevecBusinessWeekGleevec -- a highly targeted member of a class of drugs called protein-tyrosine kinase inhibitors -- was first approved by the US Food and Drug ...and more��

Novartis Third-Quarter Net Rises on Lucentis, Exforge - Bloomberg

AFPNovartis Third-Quarter Net Rises on Lucentis, ExforgeBloomberg... revenue when the company's best-sellers, Diovan for hypertension and Gleevec for leukemia, seen here, start to lose US patent protection in 2012. ...Novartis Set To Defy Health Care Reform ImpactWall Street JournalNovartis Reports $2.28 billion in Q3 EarningsWooEBDrug maker Novartis posts 10 percent increase in third-quarter net profit to ...TODAYonlineInsider Media�-Sifyall 287 news articles��

The Cancer Sleeper Cell - New York Times

The Cancer Sleeper CellNew York TimesIn 2001, word of a novel drug called Gleevec began to spread like wildfire through this community. Gleevec was the exemplar of a brand-new kind of cancer ...

Gleevec (imatinib mesylate)

Last updated on: Jan 24, 2007

Brand Name:	Gleevec
Active Ingredient:	imatinib mesylate
Strength(s):	50 mg and 100mg
Dosage Form(s):	Capsules
Company Name:	Novartis Pharmaceuticals Corporation
Availability:	Prescription only
*Date Approved by the FDA:	May 10, 2001
*Approval by FDA does not mean that the drug is available for consumers at this time. This information is provided by the U.S. Food & Drug Administration. For more information about this drug, click here.

What is Gleevec used for?

Gleevec is used to treat Gleevec is used to treat certain types of cancer including Chronic Myeloid Leukemia (CML), and Gastrointestinal Stromal Tumors (GIST).

At this time it is not known whether Gleevec will improve symptoms or help patients live longer.

Special Warnings with Gleevec:

Women of childbearing age should avoid becoming pregnant while being treated with Gleevec.

What should I tell my doctor or health care provider?

Tell your doctor if you experience swelling or weight gain from water retention.

Because Gleevec interacts with certain other medications, review all medications that you are taking with your doctor, including those that you take without a prescription.

Your health care provider may have to adjust your dose or monitor you more closely if you take certain medicines.

Examples of medications that may increase the amount of Gleevec in your blood include:

ketoconazole
itraconazole
erythromycin
clarithromycin

Examples of medications that may decrease the amount of Gleevec in your blood include:

dexamethasone
phenytoin
carbamazepine
rifampicin
phenobarbital
St. John's Wort

Gleevec may affect other medications so it is important to review all medicines that you take with your doctor.

What are some possible side effects of Gleevec? (This is NOT a complete list of side effects reported with Gleevec. Your health care provider can discuss with you a more complete list of side effects.)

Commonly reported side effects include:

Nausea
Vomiting
Fluid retention (sometimes severe)
Muscle cramps
Skin rash
Diarrhea
Heartburn
Headache

Although some of the serious side effects occur less frequently, severe side effects include severe fluid retention (edema), liver problems, and the potential for bleeding (hemorrhage), especially in the elderly.

This information is provided by the U.S. Food & Drug Administration.
For more information about this drug, click here.