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News on Avastin (bevacizumab)

Roche Q3 sales dip as top drug Avastin falters - Reuters

Roche Q3 sales dip as top drug Avastin faltersReutersVX) reported a 3 percent drop in third-quarter sales, as top-selling cancer drug Avastin faced one of its toughest periods, failing to give the Swiss ...Roche's Third-Quarter Avastin Sales WeakenToronto StarRoche's Revamp To Leave Intact Its Strategy To Drive InnovationWall Street JournalRoche turnover dips, maintains full-year forecastPharma TimesMarketWatch�-The Associated Press�-The FINANCIAL (blog)all 158 news articles��

Avastin helps in ovarian cancer but effects fade - Reuters

Avastin helps in ovarian cancer but effects fadeReutersMILAN (Reuters) - Roche's blockbuster drug Avastin helps women with ovarian cancer live longer without their disease getting worse, ...Roche Reports Positive Data For Avastin In Ovarian CancerWall Street JournalAvastin and Ovarian Cancer: Good News and BadCBS NewsAvastin, Erbitux rack up data gainsFiercePharmaRightFielders Women in Sports�-Genetic Engineering News�-dBTechnoall 68 news articles��

Cancer centers demand access to Avastin - Daily Caller

Cancer centers demand access to AvastinDaily CallerNCCN has affirmed its guidelines for using Avastin in combination with the Bristol-Myers Squibb Co. chemotherapy agent Taxol to treat metastatic breast ...Doctors vs. Bureaucrats: Are They Listening?Big Governmentall 2 news articles��

Cancer network favors Avastin — mostly - San Francisco Business Times (blog)

Cancer network favors Avastin — mostlySan Francisco Business Times (blog)Less than two months before the FDA is set to make a politically charged decision on the use of Genentech Inc.'s best-selling cancer drug, Avastin, ...NCCN Guidelines for Breast Cancer Updated; Bevacizumab Recommendation AffirmedMarketWatch (press release)FDA Continues Debate as Cancer Centers Reaffirm Avastin for Breast Cancer ...KBOIall 16 news articles��

Avastin (bevacizumab)

Last updated on: Jan 24, 2007

Brand Name:	Avastin
Active Ingredient:	bevacizumab
Strength(s):	100mg/4mL, 400 mg/16 mL
Dosage Form(s):	Injectable
Company Name:	Genetech, Inc.
Availability:	Prescription only
*Date Approved by the FDA:	February 26, 2004
*Approval by FDA does not mean that a new drugis immediately marketed and available for consumers at this time. This information is provided by the U.S. Food & Drug Administration. For more information about this drug, click here

What is Avastin used for?

Avastin is used with intravenous 5-FU based chemotherapy (IFL) as the first-treatment for patients with metastatic colon cancer (cancer of the colon or rectum that has spread to other areas of the body). IFL is a commonly used chemotherapy (medicine used to kill cancer cells) combination containing irinotecan, 5-fluorouracil (5-FU), and leucovorin for the treatment of colon cancer.

Avastin will not cure colorectal cancer that has spread. Overall, patients given Avastin plus intravenous 5-FU based chemotherapy had more tumors that shrank and survived about five months longer than patients given only intravenous 5-FU based chemotherapy. In addition, the average time before tumors restarted growing or new tumors appeared was four months longer than patients who were given only intravenous 5-FU based chemotherapy.

Special Warning(s) with Avastin:

Avastin may cause gastrointestinal perforation (holes in the stomach, intestines or colon) requiring surgery to repair.
Avastin may impair wound healing or cause wounds to open up. Avastin should not be started for at least 28 days following major surgery and full wound healing, and should be stopped before a scheduled surgery.
Some patients with non?small cell lung cancer (for which Avastin is not approved) treated with chemotherapy and Avastin had bleeding from the lung tumor, spitting up of blood, leading to death.
Avastin may cause a severe increase in blood pressure so patients receiving Avastin should have their blood pressure checked regularly.
Avastin may cause proteinuria (protein in the urine, a sign of kidney damage).
Avastin may cause congestive heart failure (failure of the heart to pump blood well).

General Precautions with Avastin:

Avastin should be used with caution in patients who are allergic to Avastin or to any of the ingredients in Avastin

Avastin may cause severe infusion reactions such as trouble breathing during the first or later doses

What should I tell my health care provider?

Tell your health care provider if you:

have or had liver or kidney problems
have high blood pressure
have congestive heart failure or other heart problems
are pregnant, are trying to become pregnant, or are breast-feeding
if you have recently had surgery or are planning to have surgery

Tell your health care provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how Avastin works or Avastin may affect how your other medicines work.

What are some possible side effects of Avastin? (This list is NOT a complete list of side effects reported with Avastin. Your health care provider can discuss with you a more complete list of side effects.)

Serious side effects include of Avastin treatment include: