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News on Actos

FDA finds link between pioglitazone and bladder cancer - The Money Times

TopNews United KingdomFDA finds link between pioglitazone and bladder cancerThe Money TimesActos (pioglitazone), the widely prescribed diabetes drug, is under investigation for possible associations with heightened risk of bladder cancer, ...Actos possibly linked to Bladder CancerLawyers and SettlementsFDA Studying Possible Link Between Pioglitazone and Bladder CancerMedscapeFDA: Diabetes drug Actos linked to bladder cancerFood ConsumerUPI.com�-BusinessWeek�-Washington Postall 258 news articles��

Heart risk from diabetes drug Actos as great as from Avandia, study finds - Los Angeles Times

Health JackalHeart risk from diabetes drug Actos as great as from Avandia, study findsLos Angeles TimesSales of Avandia, as high as $3.4 billion in 2006, have fallen to about $1.1 billion this year, while those of Actos have climbed to about $4.6 billion. ...Diabetes Drug Avandia as Safe as Actos: StudyFOXNewsActos Heart Side Effects Similar to Avandia: StudyAboutLawsuits.comStudy: Actos just as risky as AvandiaFiercePharmaNewsinferno.com�-Health Jackal�-PharmExec.comall 83 news articles��

Avandia: a PR mess for Glaxo, but not a financial one - CNNMoney

Avandia: a PR mess for Glaxo, but not a financial oneCNNMoneyIt's true that the Actos and Avandia are both derivatives of a drug called troglitazone, which was pulled from the US market in 2000 because it caused liver ...and more��

Diabetes drugs Avandia, Actos both risky - Right Juris

OverTheLimit.info (blog)Diabetes drugs Avandia, Actos both riskyRight JurisBy Andrew Research undertaken by the health insurance company, Wellpoint, indicate that for those using the diabetes drugs Avandia and Actos are both risky. ...The Diabetes Drugs, Avandia and Actos, Have The Same Amount of RisksThaindian.comHeart Risk Posed By Diabetes Drugs Avandia Same As Actos, Study SaysThaindian.comAvandia, Actos Both Risky Diabetes DrugsOverTheLimit.info (blog)OverTheLimit.info (blog)all 7 news articles��

Actos

Last updated on: Jan 24, 2007

Brand Name:	Actos
Active Ingredient:	pioglitazone
Strength(s):	15 mg, 30 mg, and 45 mg
Dosage Form(s):	Tablets
Company Name:	Takeda Chemical Industries, Ltd.
Availability:	Prescription only
*Date Approved by the FDA:	July 15, 1999
*Approval by FDA does not mean that the drug is available for consumers at this time. This information is provided by the U.S. Food & Drug Administration. For more information on this drug, click here.

What is Actos used for?

Actos, in addition to diet and exercise, improves blood sugar control in patients with type 2 diabetes (non-insulin dependent diabetes). Actos can be used alone or in combination with a sulfonylurea, metformin, or insulin when diet, exercise, and one of these agents or diet, exercise, plus Actos alone are not are not enough to control blood sugar.

Who should not take Actos?

Do not take Actos for Type 1 diabetes (juvenile diabetes) or diabetic ketoacidosis.
If you have heart failure, fluid retention or active liver disease your health care provider will evaluate you to decide if Actos is right for you.

Reports of Patients' Experiences Since Actos Became Available:

There have been reports of inflammation of the liver (hepatitis) and elevated liver enzymes. It has not been determined whether these events are directly related to Actos. It is recommended that patients taking Actos have their liver enzymes monitored periodically.

General Precautions with Actos:

Actos is in the same class of drugs as Rezulin, which has been associated with rare but serious liver injury, including liver failure leading to transplant or death. Because the liver safety profile of Actos is not fully determined yet, your doctor will do blood tests that evaluate your liver before starting you on Actos. These blood tests should be repeated every two months for the first year, then regularly after that.
Call your health care provider right away if you develop nausea, vomiting, stomach pain, a feeling of tiredness or having no energy, loss of appetite, dark urine, or jaundice (yellow coloring of eyes and skin). These may be the symptoms of liver problems.
Patients who experience an unusually rapid increase in weight or retain fluid (edema) or who develop shortness of breath or other symptoms of heart failure while on Actos should immediately report these symptoms to their health care provider.
When taking Actos with insulin or certain other oral diabetes medicines, there is a risk of your blood sugar becoming dangerously low. Ask your health care provider about symptoms of low blood sugar, conditions that make low blood sugar more likely, and what to do if you get it. Make sure to explain to family members.
If you are a woman who has not reached menopause but have not had menstrual periods; you may become pregnant unless you use an effective method of birth control. Actos, like other drugs in this class, may cause insulin resistant women to start ovulating again.
Women should tell their doctor if they notice any changes in their monthly menstrual cycle.
During periods of stress on the body, such as fever, trauma, infection, or surgery, your medication requirements may change; contact your health care provider promptly.

What should I tell my doctor or health care provider?

Women taking oral birth control pills should talk to their health care provider when taking Actos, because the effectiveness of oral birth control pills can be reduced.

Tell your health care provider if you are trying to become pregnant, are already pregnant, or are breast-feeding.

Because certain other medications may interact with Actos, review all medications that you are taking with your health care provider, including those that you take without a prescription.

What are some possible side effects of Actos? (This list is not a complete list of side effects reported with Actos. Your health care provider can discuss with you a more complete list of side effects.)